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NMN manufacturer BONTAC will take you to know Bontac Factory NMN 3.0 Enzyme Catalytic Technology

Source:bontac

Release Time: 2022-03-30 11:03:17

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Zhongshan Bontac Hesheng Biological Technology Co., Ltd. is Bontac's second wholly-owned coenzyme factory, covering an area of 16,000 square meters, and integrating international advanced coenzyme production technology, with an annual output of 100 tons of coenzyme.

Advantage

       Enzyme Catalysis             Technology Iteration

Large-scale production             Lower cost

Let us get to know the Zhongshan Bontac factory together,

Observe the application scenarios of the third-generation all-enzyme catalysis technology,

Experience the key technology of the coenzyme production system,

Appreciate the subtlety and grandeur of high-tech Coenzyme!

Protein purification

Covers an area of over 300 square meters

The filtration system covers an area of 100 square meters

Daily processing 16T new type of bacteria breaking equipment

Multiple sets of enzyme extraction, purification and immobilization systems

10 highly educated and highly skilled talents.

Comprehensive use of various protein extraction and purification methods such as crushing, heat treatment, sedimentation, adsorption, etc., to isolate a certain protein with special activity from the engineered bacteria for biocatalytic synthesis.

Whole-Enzyme Catalysis

Covers an area of over 300 square meters

7 whole enzyme production lines

10 highly educated and highly skilled talents

Use more than 3 kinds of engineering enzymes to carry out multiple catalytic reactions in a mild water phase system, and the resulting crude product does not contain toxic and harmful organic reagents and chemical synthesis impurities. At the same time, Bontac's innovative composite enzyme immobilization technology enables engineering enzymes to be reused more than 30 times, which greatly reduces production costs.

The key to enzyme catalysis lies in the development of industrial enzymes. Manufacturers without enzyme catalysis technology need to purchase commercial enzymes at high prices. Bontac has more than 600 kinds of its own enzyme library, and at the same time, it has built a rational design and directed evolution technology platform for enzymes to continuously improve the stability and catalytic efficiency of enzymes.

Product primary purification workshop

Covers an area of 1,000 square meters

20 highly educated and high-tech talents

4 sets of gram-level to ton-level purification systems

A unique seven-step purification process is used to effectively control raw material residues and other impurities, and the crude product synthesized by biocatalysis is purified into high-quality raw material products. The workshop is equipped with multiple high-efficiency liquid phase equipment to monitor the purification process in real time.

One 100,000 class clean workshop

Covering an area of 2,000 square meters, it is divided into raw material production area, tablet production area, and finished product storage area.

Including: microfiltration ultrafiltration nanofiltration system, crystallization system, freeze drying and vacuum equipment, granulation and powder production line, packaging line, 150-square-meter cold storage and freezer (store 10 tons of finished products).

1. Nanofiltration

Multiple sets of microfiltration, ultrafiltration and nanofiltration systems can effectively intercept salt, 0.001~50um suspended solids, bacteria, viruses, bacterial endotoxins, plasticizers and other pollutants, and strictly control product quality.

 

2. Crystallization/drying

The daily processing capacity of the crystallization platform reaches 600 kg, and the -10~50℃ temperature control system meets the stepped temperature control process requirements of the exclusive crystallization patent technology, so that the product purity can reach more than 99.5%.

It has multiple imported freeze drying and vacuum drying equipment to effectively control product moisture and improve product stability.

3. Crushing or making films

It is equipped with post-processing equipment such as freezing crushing, granulating, granulating, and vibrating screen, which can realize the production of products with different particle sizes and densities.

4. Packaging

With multiple tableting candy production equipment such as mixing, tableting, coating, blister packaging, soft aluminum packaging, etc., it can meet the production needs of different specifications of tablets.

 

Quality Inspection Center

Covering an area of 600 square meters

GMP level management

41 testing equipment

Over 50 test indicators

24+ highly educated quality inspectors

Part of the testing equipment of the quality inspection center

 

The quality inspection technology is strong, the management system is established in accordance with the requirements of GMP regulations, and the inspection is carried out in strict accordance with the national food safety standards and the Chinese Pharmacopoeia to ensure the reliability, accuracy and management standardization of the test results. The test items cover: physical and chemical, purity, content , Ash content, color difference, bulk density, residual solvent, moisture, heavy metal detection, microbial detection, enzyme activity and other indicators to meet the detection of various indicators of the product.

 

It has 2 standard public laboratories, 1 pilot scale-up laboratory, 1 detection and analysis room and drying laboratory, etc., equipped with a complete set of coenzyme purification equipment and testing instruments, which can realize the trial production of gram-level, 100-gram-level, and kilogram-level R&D samples .

Quality Coenzymes, BONTAC Serves!

Bontac has forged a complete production system, intellectual property rights and production experience. Facing the market, Bontac refines every link, exquisite every technology, precise every service, adapts to diversified market demands with high-quality quality, provides better coenzyme products, and makes the world healthy and beautiful because of "coenzyme" .