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Why Choose BONTAC?
Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
Unlocking the Secrets of NMN: Mechanism and Effects on Health
In the world of cutting-edge biotechnology, few compounds have garnered as much attention as Nicotinamide Mononucleotide, or NMN. This revolutionary molecule is taking the health and wellness industry by storm, and for a good reason. In this article, we will explore what NMN is, its mechanisms, and its profound effects on health.
What is NMN?
Nicotinamide Mononucleotide (NMN) is a naturally occurring compound found in all living cells. It plays a crucial role in the production of Nicotinamide Adenine Dinucleotide (NAD+), a coenzyme that is essential for various biological processes in the body. NAD+ levels tend to decline as we age, contributing to various age-related health issues. NMN supplementation aims to boost NAD+ levels, potentially reversing or mitigating these issues.
The Mechanism: How NMN Works
NMN is a precursor to NAD+, meaning it is converted into NAD+ in our cells. This transformation is vital because NAD+ is involved in several critical cellular functions, including energy metabolism, DNA repair, and gene expression. When NMN is administered, it enhances the NAD+ levels, providing the body with more of this essential coenzyme.
Effects of NMN on Health
The increased availability of NAD+ through NMN supplementation has far-reaching effects on health and wellness:
1、Energy Production: NAD+ is a key player in the production of adenosine triphosphate (ATP), the body's primary energy currency. More NAD+ means more energy for the body's cells, potentially leading to increased vitality and stamina.
2、Cellular Repair: NAD+ supports DNA repair mechanisms, helping to maintain the integrity of the genome. This is crucial in preventing mutations that can lead to aging and the development of diseases.
3、Sirtuin Activation: NAD+ is necessary for the activation of sirtuins, a family of proteins that regulate cellular health. Sirtuins have been associated with longevity and can help combat age-related issues.
4、Metabolic Health: Increased NAD+ levels can have a positive impact on metabolic processes, potentially aiding in weight management and preventing metabolic disorders.
5、Neuroprotection: Some studies suggest that NAD+ augmentation with NMN may help protect against neurodegenerative diseases like Alzheimer's and Parkinson's.
6、Cardiovascular Health: NAD+ plays a role in maintaining healthy blood vessels, which can contribute to cardiovascular health.
7、Immune System Support: NAD+ helps regulate the immune system, potentially enhancing its ability to respond to infections and diseases.
Is NMN Safe?
NMN is generally considered safe for use, and it has been extensively studied in animal models. However, more research is needed to fully understand its long-term effects in humans. As with any supplement, it's crucial to consult with a healthcare professional before incorporating NMN into your health regimen.
In conclusion, NMN is a remarkable compound with the potential to revolutionize health and wellness. By increasing NAD+ levels, NMN supplementation can positively impact energy levels, cellular repair, metabolic health, and more. As the biotechnology industry continues to explore the possibilities of NMN, it may become a key player in the quest for longevity and enhanced well-being.
At Bontac, we are at the forefront of providing high-quality NMN raw materials for businesses in the health and wellness industry. Our commitment to quality and innovation ensures that our partners can harness the full potential of NMN. Contact us to learn more about our NMN offerings and how we can assist your business in delivering cutting-edge products to the market.
NMN: Manufacturing, Preparation, and Clinical Trials
In the realm of cutting-edge biotechnology, one compound has taken center stage for its potential to transform the landscape of health and wellness. Nicotinamide Mononucleotide (NMN) has been the subject of significant research, with a focus on its manufacturing and preparation processes, as well as its clinical trials.
NMN Manufacturing and Preparation
NMN is a derivative of niacin (vitamin B3) and is a precursor to Nicotinamide Adenine Dinucleotide (NAD+), a critical coenzyme involved in various cellular functions. Producing NMN involves several steps to ensure its purity and effectiveness:
1、Extraction: NMN can be synthesized from niacin or obtained through the extraction of natural sources like milk. These sources contain precursors that can be converted into NMN.
2、Purification: After extraction, NMN must undergo purification processes to remove impurities and achieve the desired level of purity. High purity is essential to ensure the efficacy and safety of NMN supplements.
3、Synthesis: Chemical synthesis is another method for manufacturing NMN. This involves converting niacin into NMN through a series of chemical reactions. This method offers precise control over the NMN production process.
4、Quality Control: Throughout the manufacturing process, rigorous quality control measures are applied to guarantee the safety and effectiveness of the final product. These measures include testing for purity, potency, and absence of contaminants.
The manufacturing and preparation of NMN require careful attention to detail to ensure that the end product meets the highest standards for quality and safety.
NMN Clinical Trials
Clinical trials related to NMN have provided valuable insights into its potential benefits. These trials have explored various aspects of NMN supplementation, shedding light on its safety and effectiveness:
1、Aging and Longevity: Some studies have suggested that NMN supplementation may have a positive impact on aging-related issues, potentially extending lifespan and improving overall health.
2、Metabolic Health: Clinical trials have examined the effects of NMN on metabolic health. Preliminary results have indicated potential benefits in areas such as glucose metabolism and insulin sensitivity.
3、Cardiovascular Health: Research has investigated the impact of NMN on cardiovascular health. Promising findings have emerged regarding blood vessel function and blood pressure regulation.
4、Neuroprotection: NMN's potential neuroprotective properties have been studied in the context of neurodegenerative diseases. While more research is needed, early results have been encouraging.
5、Safety and Tolerability: Clinical trials have also focused on the safety and tolerability of NMN. Generally, NMN has been well-tolerated, with few reported side effects.
It's important to note that while these clinical trials have provided valuable data, the research on NMN is ongoing, and more extensive studies are needed to establish its long-term safety and efficacy.
Bontac, a leading biotech enterprise, is at the forefront of providing high-quality NMN raw materials. Our commitment to innovation and quality ensures that our partners can develop products that meet the highest standards in the health and wellness industry. With a strong emphasis on research and development, we aim to contribute to the ongoing exploration of NMN's potential benefits.
In conclusion, NMN manufacturing and preparation involve a series of rigorous steps to ensure the production of high-quality, safe supplements. Clinical trials have provided promising insights into NMN's potential benefits in areas such as aging, metabolic health, cardiovascular health, and neuroprotection. As research on NMN continues, Bontac remains dedicated to providing the industry with the finest NMN raw materials for the development of innovative health and wellness products.
Best NMN Powder: Factory, Purity, and Supplier
When searching for the best NMN (Nicotinamide Mononucleotide) powder, three key aspects play a pivotal role in your decision-making process. This comprehensive guide dives into the world of NMN, highlighting the critical factors that set the best NMN powder apart. We'll explore the best NMN powder factory, delve into the significance of purity, and introduce you to a reliable NMN powder supplier.
- Best NMN Powder Factory :
- State-of-the-Art Manufacturing:
The foundation of premium NMN powder begins at the factory. Look for a manufacturer that boasts state-of-the-art facilities, adhering to the highest standards of production. Top-tier factories utilize cutting-edge technology and rigorous quality control to ensure the finest NMN powder.
- Research and Development:
Leading NMN powder factories invest in robust research and development. They actively engage in scientific studies and collaborate with experts to continuously enhance their product's quality and effectiveness.
- Quality Certifications:
Reputable factories hold certifications such as GMP (Good Manufacturing Practices) and ISO, underscoring their commitment to quality, safety, and consistency. These certifications are a testament to their dedication to producing the best NMN powder.
- Best NMN Powder Purity (approx. 200 words):
- High Purity Standards:
The purity of NMN powder is paramount. Opt for a product with a purity rating of 99% or higher. The best NMN powder is free from impurities and excipients, ensuring maximum potency.
- Independent Testing:
To validate purity claims, the best NMN powder undergoes independent third-party testing. These tests provide transparency and assurance that what you're purchasing aligns with its purity claims.
- No Additives or Fillers:
A top-quality NMN powder doesn't contain additives or fillers. The absence of unnecessary substances ensures you're receiving a pure and potent product.
- Best NMN Powder Supplier:
- Reliability and Reputation:
Selecting the right supplier is crucial. Look for a supplier with a stellar reputation for delivering consistent, high-quality NMN powder. Online reviews and testimonials can offer insights into their reliability.
- Transparent Sourcing:
A trustworthy supplier should be transparent about the sourcing and production of their NMN powder. Clear information about their supply chain and production process demonstrates their commitment to quality.
- Customer Support:
The best NMN powder supplier offers excellent customer support. Whether you have questions or need assistance, a responsive and knowledgeable support team is a valuable asset.
In the quest for the best NMN powder, the factory, purity, and supplier are non-negotiable elements. By opting for a manufacturer with cutting-edge facilities, a commitment to purity, and a reliable supplier with a sterling reputation, you'll embark on a journey towards reaping the full benefits of NMN. The best NMN powder is not just a product; it's a commitment to your well-being.
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Fathoming Out the Role of NMN in Maintaining the Colon Health of Ageing Mice
Introduction The gut is a diverse and dynamic microbiotic system. There are about 100 trillion microorganisms in the gut, which is mainly composed of anaerobic, partially anaerobic, and aerobic bacteria. In the process of ageing, the intestinal tract may show an increase in the permeability of the epithelial barrier and impaired tight junction proteins. Notably, supplementing β-Nicotinamide mononucleotide (NMN) to elevate NAD+ level has been proved to prolong life and maintain the colon health in ageing Mice. Research protocol Zmpste24−/− mice are frequently used in the construction of the prematurely ageing model, due to their features of slow weight gain, malnutrition and progressive hair loss, with a short median survival of about 20 weeks. Herein, to fathom out the role of NMN in maintaining the colon health of ageing mice, Zmpste24−/− mice aged 5-7 weeks are orally gavaged with phosphate-buffered saline (PBS), or NMN at 100/300 mg kg−1 every other day until natural death. Likewise, natural ageing C57BL/6 mice aged 10 months old are subjected to the oral gavage of PBS or NMN at 300 mg kg−1, serving as the the control. During experiments, the body weight of mice is recorded, and their frailty index and fecal samples are detected. The life span and frailty indices in Zmpste24-/- mice after NMN treatment NMN extends the healthy and median lifespan of Zmpste24−/−improves the Zmpste24−/− ageing phenotype. Specifically, the median lifespan of the mice is increased from 21.4 weeks to 25.7 weeks post NMN intervention, with more than 20% growth. Also, NMN effectively increases body weight. Meanwhile, mice have better overall health after NMN treatment, as manifested by the slowly increasing trend towards Sinclair’s frailty indices. The role of NMN in the intestinal tract of ageing mice NMN adjusts the activity of genes involved in ageing mice colons. Simply put, in the presence of NMN supplement, the protein level of transcriptional regulator P53 is reduced, while the expression levels of ageing marker Sirt1, NMNAT2 and NMNAT3 are elevated. NMN improves the pathology of intestinal epithelial cells and intestinal permeability, as evidenced by the upregulation of intestinal tight junction protein (Claudin1,) and the number of goblet cells, the elevated release of anti-inflammatory factor (IL-10), and the increasing beneficial intestinal bacteria (Akkermansia muciniphila and Bifidobacterium pseudolongum). Conclusion NMN supplementation exerts a protective effect on colon mucosa by controlling the activity of genes involved in ageing, intestinal stem cell differentiation and improving intestinal flora homeostasis, which may be a viable strategy for maintaining healthy ageing in the gut. Reference Yanrou Gu, Lidan Gao, Jiamin He et al. β-Nicotinamide mononucleotide supplementation prolongs the lifespan of prematurely aged mice and protects colon function in ageing mice. Food Funct., 2024 (15): 3199-3213. DOI: 10.1039/D3FO05221D BONTAC NMN BONTAC is the pioneer of NMN industry and the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Notably, BONTAC is the NMN raw material supplier of famous David Sinclair team at the Harvard University, who uses the raw materials of BONTAC in a paper titled “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BOMNTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
Anti-inflammatory Function of NMN in Macrophages via IDO1/Kynurenine/AhR Axis
1. Introduction Nicotinamide mononucleotide (NMN) supplementation has been suggested to hamper the inflammatory responses via restoring NAD+ level and downregulating the expression of Cyclooxygenase-2 (COX-2). Strikingly, both Aryl hydrocarbon receptor (AhR) and Indoleamine 2,3-Dioxygenase 1 (IDO1), two key enzymes for kynurenine production, can mediate the anti-inflammatory function of NMN in RAW 264.7 macrophages. 2. The alleviated inflammatory response in the presence of NMN supplementation For deciphering the impact of NMN in vivo, mice are subjected to daily intraperitoneal (i.p.) injection of NMN (500 mg/kg) for consecutive 6 days, followed by i.p. injection of lipopolysaccharides (LPS) (5 mg/kg) or alum (700 μg) on day 7. It is discovered that NMN supplementation suppresses LPS- or alum-induced inflammation in mice, as manifested by the downregulation of proinflammatory cytokines (IL-6 and IL-1β) and proinflammatory enzyme (COX-2). 3. The necessity of AhR for NMN-mediated inhibition of inflammatory response in macrophages AhR, a ligand-activated transcription factor, can mediate the anti-inflammatory function of NMN upon LPS treatment in RAW264.7 cells. Specifically, NMN reduces the expression of COX-2 in cells in bearing AHR. On the contrary. AhR inhibitor (CH223191) deprives the downregulation of IL-6, IL-1β and COX-2 caused by NMN treatment. Likewise, NMN treatment fails to reduce the expression levels of IL-6, IL-1β, and COX-2 in AhR knockout cells. 4. The importance of IDO1/kynurenine/AhR axis in the anti-inflammation function of NMN IDO1 is the rate-limiting enzyme in tryptophan catabolism to produce kynurenine, a metabolic intermediate in NAD+ de novo synthesis pathway. Kynurenine can promote the translocation of AhR from the cytoplasm to nucleus, thereby exerting an anti-inflammatory effect. NMN inhibits LPS-induced inflammation in a IDO1-kynurenine dependent manner in macrophages. 5. Conclusion NMN supplementation mitigates COX-2-associated inflammatory responses by activating lDO-kynurenine-AhR pathway, providing new insights into NAD* regulation in macrophage activation. Reference Liu J, Hou W, Zong Z, et al. Supplementation of nicotinamide mononucleotide diminishes COX-2 associated inflammatory responses in macrophages by activating kynurenine/AhR signaling. Free Radic Biol Med. Published online February 8, 2024. doi:10.1016/j.freeradbiomed.2024.01.046 BONTAC NMN BONTAC is the pioneer of NMN industry and the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Notably, BONTAC is the NMN raw material supplier of famous David Sinclair team at the Harvard University, who uses the raw materials of BONTAC in a paper titled “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BOMNTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
NMN: the Dawn for Patients with Amyotrophic Lateral Sclerosis
1. Introduction Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects the motion-related nerve cells in the brain and spinal cord. The disease is featured by the death of upper and lower motor neurons (MNs) and manifested by progressive muscle atrophy and weakness, culminating in immobility to paralysis, with the body gradually frozen as if by ice. Patients with this disorder generally have a low survival rate and life quality. At present, there is no effective way to cure this disease, but early invention has a positive significance in improving the symptoms of patients and delaying the progression of disease. Remarkably, dietary NMN supplementation has been uncovered to be beneficial against ALS, which can enhance the motor and function of neuromuscular junctions (NMJs) in ALS, bringing a glimpse of hope for ALS patients. 2. The improved healthspan and reduced motor dysfunction in ALS mice post dietary NMN supplementation The median lifespan of ALS mice administrated with or without NMN is 143 days and 138 days, respectively, hinting that NMN supplementation in diet has a modest effect on lifespan extension. Relative to those without dietary NMN supplementation, NMN-treated ALS mice shows a slower motor impairment in both rotarod and hanging wire tests, with a two-week delay in dysfunction, despite no difference in body weight loss during testing period. When compared with those in the absence of dietary NMN supplementation, ALS mice administrated with NMN are more active, with increased travel distance, elevated mean speed and reduced immobile time. In addition, NMN diet prevents ALS-induced gait impairments, as manifested by the improved forelimb and hindlimb stride length in NMN-treated ALS mice. 3. The alleviating effect of NMN on the function of NMJs in ALS NMJs are one of the earliest affected site in ALS, which are benefited greatly from NMN diet. In addition to improving the length and breadth of the motor endplate, dietary NMN supplementation also ameliorates the impairment of NMJ function and reduce the semitendinosus muscle mass in ALS mice. Furthermore, NMN conspicuously elevates the innervation ratio of NMJs in ALS mice. Dietary NMN supplementation strengthens synaptic function at NMJ in ALS, while diminishing NMJ and intermyofibrillar (IMF) mitochondrial abnormalities. With a great detail, NMN prominently increases Feret's diameter of mitochondria and restores mitochondria circularity in ALS mice. 4. Conclusion Dietary NMN supplementation can modestly extend lifespan and significantly enhance healthspan by improving motor performance and NMJ function in ALS mice, opening up new opportunities for the future treatment of ALS. Reference Lundt S, Zhang N, Polo-Parada L, et al. Dietary NMN supplementation enhances motor and NMJ function in ALS. Exp Neurol. Published online January 22, 2024. doi:10.1016/j.expneurol.2024.114698 BONTAC NMN BONTAC is the pioneer of NMN industry and the first manufacturer to launch NMN mass production, with the first whole-enzyme catalysis technology around the world. At present, BONTAC has become the leading enterprise in niche areas of coenzyme products. Notably, BONTAC is the NMN raw material supplier of famous David Sinclair team at the Harvard University, who uses the raw materials of BONTAC in a paper titled “Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging”. Our services and products have been highly recognized by global partners. Furthermore, BONTAC has the first national and the only provincial independent coenzyme engineering technology research center in Guangdong, China. The coenzyme products of BONTAC are widely used in fields such as nutritional health, biomedicine, medical beauty, daily chemicals and green agriculture. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.