The Immuno-Enhancing Effect of Rh2-L on Double Emulsion Adjuvant Against FMD

The Immuno-Enhancing Effect of Rh2-L on Double Emulsion Adjuvant Against Foot-and-Mouth Disease



1. Introduction

At present, vaccine is the preferred option for the prevention of foot-and-mouth disease (FMD), for which the adjuvant is essential due to its strong role in boosting immune response associated with vaccine antigens.

Herein, Rh2 liposomes (Rh2-L) are prepared by ethano injection methods, then loaded into a double emulsion adjuvant and emulsified into a Water-in-Oil-in-Water (W/O/W) emulsion, together with FMDV antigen, for the prevention of FMD.

2. About FMD

FMD, also known as aphthous fever, is a viral and fulminating infectious disease in which the foot-and-mouth disease virus (FMDV) violates hoofed livestock such as cattle, pigs and sheep. Since FMD is a zoonotic disease with high incidence and fast transmission speed, FMD vaccination is significant for those with long-term contact with livestock or low immunity such as the herders, veterinarians and children.

3.The significance of transform Rh2 into Rh2-L

By transformation of Rh2 into Rh2-L, on the one hand, the poor solubility and hemolysis of Rh2 can be mitigated to a large extent. On the other hand, Rh2-L functions as a liposome. Noteworthily, liposome itself has been revealed to be an adjuvant in vaccine design to improve immune response by interacting with antigen-presenting cells (APCs), increasing the representation of immune stimulants to APCs, and stimulating innate immunity.

4. The immune-enhancing effect of Rh2-L on FMD vaccine

Rh2-L has a immune-enhancing effect, as evidenced by an increase in humoral and cellular immune responses. In the FMDV model, the group of the FMD vaccine prepared with double emulsion adjuvants containing Rh2-L presents a more desirable protective effect relative to other groups. This group has a higher neutralizing antibody titer, stronger lymphocyte proliferation responses, and higher levels of cellular and humoral immune cytokine production, including IFN-γ and IL-4.

5. Conclusion

Rh2-L can further boost the immune effect of the double emulsion adjuvant against foot-and-mouth disease, which may be a promising and powerful platform for subunit vaccine adjuvant.

6. Reference

Saiya Miao, Qiufang Jing, Xuanyu Wang, et al. “Immuno-Enhancing Effect of Ginsenoside Rh2 Liposomes on Foot-and-Mouth Disease Vaccine”. Molecular Pharmaceutics. 2024 21 (1), 183-193. DOI: 10.1021/acs.molpharmaceut.3c00733

BONTAC advantages

BONTAC is ·the first enterprise in China to provide mass production of ginsenosides (Rh2) by enzymatic synthesis. BONTAC has unique Bonzyme enzymatic synthesis technology. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC has more than 160 invention patents, with strict third-party self-inspection. Both the high-quality product and excellent service can be better ensured here. BONTAC has 12 years of industry experience, which is worthy of your trust. 

Disclaimer

This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. 

Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.

 

Get In Touch


Recommend Read

  • The 24th SupplySide West


    On October 17,2019-18, the 24th western American plant extracts, health and innovation raw materials exhibition (SupplySide West) in Las Vegas Mandela hotel convention and exhibition center, is hosted by the INFORMA, wit

  • Hi & Fi Asia-China 2022


    The 23rd Healthy Natural Raw materials, food ingredients China Exhibition opened in Shanghai National Convention and Exhibition Center Bangtai Biological with the third generation of total enzyme catalytic technology C p

  • The 20th World Pharmaceutical Raw Materials China Exhibition


    From December 16 to 18,2020, the 20th World Pharmaceutical Raw Materials China Exhibition (CPhI China 2020) was successfully held in Shanghai New International Expo Center. Bangtai Biological Engineering (Shenzhen) Co.,

  • Healthy China 2021 Nutrition and Healthy Food Conference


    From July 8th to July 9th, 2021, "Healthy China 2021 Nutrition and Healthy Food Conference" (HFIC) was grandly held in Hangzhou International Expo Center! Bangtai Biological Engineering (Shenzhen) Co., LTD. (he

  • The Importance of NAD Metabolism in White Adipose Tissue


    1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation and gene expression, in addition to controlling glucose metabolism. White adipose tiss

Leave Your Message