The Miraculous Potency of NR-CL on Mitigating Ischemia-induced Hippocampal Damage and Maintaining Cognitive Function
2. The ameliorating impact of NRC upon ischemia-induced cognitive deficits
Ischemia-induced cognitive deficits are ameliorated post NRC treatment. Specifically, NRC treatment improves the learning ability of mice, as evidenced by the shorter latency and the decreased path length. The hippocampal protection provided by NRC contributes to the recovery of spatial learning and memory after the ischemic insult.
3. Reduction of the infarct volume in the hippocampus post acute NRC treatment
After ischemia, there are deformed cell bodies, condensed nuclear chromatin, increased intracellular cell gaps, loosened cell arrangements and blurred visible staining in the damaged pyramidal neurons. NRC treatment partially offsets these morphological changes.
Figure 2 Acute NRC treatment reduces the hippocampal infarct volume.
4. Recovery of neuronal damage in the hippocampus post acute NRC treatment
After ischemia, brain damage emerges due to energy crisis-induced mitochondrial dysfunction, followed by the cell loss and neuronal apoptosis. NRC treatment leads to an increase in the number of positive cells, signifying the recovery of local neuronal loss.
Figure 3 Acute NRC treatment attenuates neuronal loss in the hippocampus.
5. Upregulation of NAD and ATP levels in the hippocampus post acute NRC treatment
By repleshing the production of NAD, acute treatment with NRC, to some extent, can salvage the energy supply in the hippocampus, which conspicuously enhances the recovery of ATP level.
Collectively, acute NRC treatment increases the energy supply and reduces the neuronal loss to protect the hippocampus, thereby facilitating the recovery of cognitive function.
NR-CL (ie. NRC) is a very promising component of health care products and has a wide range of application prospects. Before use, one should follow the guidance of professionals. At the same time, attention should be paid to reasonable intake and safe use to avoid the adverse effects of excessive use.
Cheng, Yin-Hong et al. “Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury.” Neurochemical research vol. 47,8 (2022): 2244-2253. doi:10.1007/s11064-022-03610-3
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