The Miraculous Potency of NR-CL on Ischemia-induced Hippocampal Damage

The Miraculous Potency of NR-CL on Mitigating Ischemia-induced Hippocampal Damage and Maintaining Cognitive Function


1 Introduction

Nicotinamide riboside (NR), a derivative of vitamin B3, is a new type of bioactive substance, which can be generated by binding a carbohydrate molecular ribose with nicotinamide (also known as niacin or vitamin B3). Nicotinamide riboside chloride (NRC/NR-CL) is a chloride salt form of NR. In daily life, NR-CL can be taken from NR supplements and food such as meat, fish and cereals. 
A recent study has revealed that NR-CL protects the hippocampus and ultimately promotes the recovery of cognitive function after brain ischemia.


2. The ameliorating impact of NRC upon ischemia-induced cognitive deficits 

Ischemia-induced cognitive deficits are ameliorated post NRC treatment. Specifically, NRC treatment improves the learning ability of mice, as evidenced by the shorter latency and the decreased path length. The hippocampal protection provided by NRC contributes to the recovery of spatial learning and memory after the ischemic insult. 

Figure 1 Acute NRC treatment potentiates cognitive recovery after ischemia

3. Reduction of the infarct volume in the hippocampus post acute NRC treatment

After ischemia, there are deformed cell bodies, condensed nuclear chromatin, increased intracellular cell gaps, loosened cell arrangements and blurred visible staining in the damaged pyramidal neurons. NRC treatment partially offsets these morphological changes.

Figure 2 Acute NRC treatment reduces the hippocampal infarct volume.


4. Recovery of neuronal damage in the hippocampus post acute NRC treatment

After ischemia, brain damage emerges due to energy crisis-induced mitochondrial dysfunction, followed by the cell loss and neuronal apoptosis. NRC treatment leads to an increase in the number of positive cells, signifying the recovery of local neuronal loss. 

Figure 3 Acute NRC treatment attenuates neuronal loss in the hippocampus.


5. Upregulation of NAD and ATP levels in the hippocampus post acute NRC treatment

By repleshing the production of NAD, acute treatment with NRC, to some extent, can salvage the energy supply in the hippocampus, which conspicuously enhances the recovery of ATP level.


6. Conclusion

Collectively, acute NRC treatment increases the energy supply and reduces the neuronal loss to protect the hippocampus, thereby facilitating the recovery of cognitive function.

NR-CL (ie. NRC) is a very promising component of health care products and has a wide range of application prospects. Before use, one should follow the guidance of professionals. At the same time, attention should be paid to reasonable intake and safe use to avoid the adverse effects of excessive use.


Cheng, Yin-Hong et al. “Acute Treatment with Nicotinamide Riboside Chloride Reduces Hippocampal Damage and Preserves the Cognitive Function of Mice with Ischemic Injury.” Neurochemical research vol. 47,8 (2022): 2244-2253. doi:10.1007/s11064-022-03610-3

Product advantages and features of BONTAC NR-CL

* Bonzyme Whole-enzymatic method (environmental-friendly; no harmful solvent residues)

* Unique Bonpure seven-step purification technology, with higher product content and higher conversion rate

* Self-owned factories and a number of international certifications to ensure high quality and stable supply of products

* One-stop customized service for product solution



This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. 

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