NMN administration improves heart failure because of mitochondrial dysfunction

Unlock the Cover of NMN Administration to Protects against Heart Failure



 

Myocardial mitochondria are primary sites of myocardial energy metabolism. Mitochondrial disorders are associated with various cardiac diseases. Mitochondrial translation defects cause not only mitochondrial dysfunction but also decreased nicotinamide adenine dinucleotide (NAD+ ) levels, leading to impaired lysosomal acidification and autophagy. In this study, reseachers investigated whether nicotinamide mononucleotide (NMN) administration, which compensates for decreased NAD+ levels, improves heart failure because of mitochondrial dysfunction. NMN administration reduced damaged lysosomes and improved autophagy, thereby reducing heart failure and extending the lifespan in p32cKO mice. The study found that lysosomal damage due to mitochondrial dysfunction induced ferroptosis, involving the accumulation of iron in lysosomes and lipid peroxide.

1. NMN administration improves lysosomal function and reduces heart failure in mice with mitochondrial dysfunction

The study found that NMN administration improved lysosomal function and reduced heart failure in mice with mitochondrial dysfunction. Specifically, NMN supplementation reduced damaged lysosomes and improved autophagy, leading to a reduction in heart failure and an extension of lifespan in these mice. These findings suggest that NMN supplementation strongly affects lysosomal function, offering a potential therapeutic approach for heart failure.(as shown in Figure 1)

nmn
Figure 1 

2. NMN administration reduces ferroptosis in the heart

NMN administration reduced ferroptosis in the heart, which is a form of cell death caused by the accumulation of iron and lipid peroxidation. This reduction in ferroptosis was associated with an increase in glutathione peroxidase 4 (GPX4) expression, which is a key enzyme involved in the prevention of lipid peroxidation. These findings suggest that NMN administration may protect against heart failure by reducing ferroptosis in the heart.

nmn heart failure
Figure 2

3. NMN administration restores gene expression in the heart

The study found that NMN administration restored the expression of several genes in the heart that were downregulated in mice with mitochondrial dysfunction. These genes are involved in various cellular processes, including mitochondrial function, oxidative stress, and inflammation. These findings suggest that NMN administration may improve heart function by restoring gene expression in the heart.

nmn lab
Figure 3

4. NMN administration improves mitochondrial function in the heart

The study found that NMN administration improved mitochondrial function in the heart, as evidenced by an increase in mitochondrial DNA copy number and the expression of genes involved in mitochondrial biogenesis. These findings suggest that NMN administration may protect against heart failure by improving mitochondrial function in the heart.

nmn lab 2
Figure 4

Mitochondria are the main organelles for energy production, and mitochondrial dysfunction causes serious diseases associated with aging. We previously found that (1) the expression of NAD+ synthase expression was decreased owing to mitochondrial dysfunction and lysosomal and autophagic function was impaired owing to decreased NAD+ biosynthesis (Yagi et al, 2021) as an additional cause of the exacerbation of chronic heart failure associated with aging. This study shows that NMN administration improves lysosomal function and cell death by ferroptosis when NAD+ levels are improved. In the near future, we aimed to apply NMN to clinical use in aging- and lysosome-related diseases.


Reference
Mikako Yagi, Yura Do, Takeshi Uchiumi, et al. Improving lysosomal ferroptosis with NMN administration protects against heart failure. doi: 10.26508/lsa.202302116

Disclaimer

This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. 
 

Get In Touch


Recommend Read

  • The 24th SupplySide West


    On October 17,2019-18, the 24th western American plant extracts, health and innovation raw materials exhibition (SupplySide West) in Las Vegas Mandela hotel convention and exhibition center, is hosted by the INFORMA, wit

  • Hi & Fi Asia-China 2022


    The 23rd Healthy Natural Raw materials, food ingredients China Exhibition opened in Shanghai National Convention and Exhibition Center Bangtai Biological with the third generation of total enzyme catalytic technology C p

  • The 20th World Pharmaceutical Raw Materials China Exhibition


    From December 16 to 18,2020, the 20th World Pharmaceutical Raw Materials China Exhibition (CPhI China 2020) was successfully held in Shanghai New International Expo Center. Bangtai Biological Engineering (Shenzhen) Co.,

  • Healthy China 2021 Nutrition and Healthy Food Conference


    From July 8th to July 9th, 2021, "Healthy China 2021 Nutrition and Healthy Food Conference" (HFIC) was grandly held in Hangzhou International Expo Center! Bangtai Biological Engineering (Shenzhen) Co., LTD. (he

  • The Importance of NAD Metabolism in White Adipose Tissue


    1. Introduction Nicotinamide adenine dinucleotide (NAD) compartmentalized in adipocytes can modulate adipocyte differentiation and gene expression, in addition to controlling glucose metabolism. White adipose tiss

Leave Your Message