Give you a brief introduction to nmn powder | Bontac

Give you a brief introduction to nmn powder | Bontac

Beta-Nicotinamide mononucleotide (NMN) is an intermediate of NAD+ biosynthesis produced from nicotinamide through nicotinamide phosphoribosyl transferase (NAMPT) and also referred to as NMN or nicotinamide ribotide. In recent studies of NMN applications to prevention and diagnosis of age-dependent diseases such as diabetes, neurodegenerative disorder, cardiac disease etc., it has become one of hottest biomarkers on discussion for anti-aging, lately. As one of worldwide leading manufacturers, we are now providing highly qualified fully physiologically active, beta-Nicotinamide mononucleotide (NMN) as to support basic research in not only Academia but also Pharmaceuticals.
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Advantages of NMNH

NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity(up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service

Advantages of NADH

NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service

Advantages of NAD

NAD:  1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products

Advantages of MNM

NMN:  1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity(up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University

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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.

As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.

In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.

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NMN powder efficacy in health

NMN was only considered as a source of cellular energy and an intermediate in NAD+ biosynthesis, currently, the attention of the scientific community has been paid on anti-aging activity and a variety of health benefits and pharmacological activities of NMN which are related to the restoring of NAD+. Thus, NMN has therapeutic effects towards a range of diseases, including age-induced type 2 diabetes, obesity, cerebral and cardiac ischemia, heart failure and cardiomyopathies, Alzheimer’s disease and other neurodegenerative disorders, corneal injury, macular degeneration and retinal degeneration, acute kidney injury and alcoholic liver disease.

NMN powder efficacy in health

BONTAC NMN product features and advantages

1、“Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder 
2、Exclusive“Bonpure”seven-step purification technology, high purity(up to 99.9%) and stability of production of NMN powder 
3、Industrial leading technology: 15 domestic and international NMN patents
4、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMN powder  
5、Multiple in vivo studies show that Bontac NMN powder is safe and effective
6、Provide one-stop product solution customization service
7、NMN raw material supplier of famous David Sinclair team of Harvard University.

BONTAC NMN product features and advantages

NMN powder manufacturing method

NMN powder in general is typically produced via chemical or enzymatic synthesis, or fermentation biosynthesis. There are pros and cons to all three methods.
Chemical synthesis is expensive and labor intensive, and all raw ingredients used are categorized as “unnatural,” i.e., not from biological systems. There are, however, some advantages from the manufacturer’s perspective. The yield is well suited to mass NMN powder production, and all of those unnatural raw ingredients can be carefully controlled. But there are a number of drawbacks as well. Some of the solvents used in the manufacturing process are seriously bad from an environmental standpoint, and impurities and by-products can be challenging to remove from the finished product – that’s seriously bad for the consumer.
Enzymatic production of NMN powder, on the other hand, is considered a “green preparation method.” Like the chemical route, it’s pricey, but it offers a higher yield and impressively high purity. The finished NMN ticks all the boxes – stable, easily absorbed, lightweight, low density, and a low molecular structure.
Fermentation has also been explored as a method of producing NMN, but yield, though high quality, is pretty abysmal, so many supplement companies quite sensibly look to other, more efficacious processes.

NMN powder manufacturing method
User Reviews

What users say about BONTAC

BONTAC is a reliable partner that we have been working with for many years. The purity of their coenzyme is very high. Their COA can achieve relatively high test results.

Front

I discovered BONTAC in 2014 because David's article in cell about NAD and NMN related showed that he used BONTAC's NMN for his experimental material. Then we found them in China. After so many years of cooperation, I think it is a very good company.

Hanks

I think green, healthy and high purity are the advantages of BONTAC's products compared with others. I still work with them to this day.

Phillip

In 2017, we chose BONTAC's coenzyme, during which our team encountered many technical problems and consulted their technical team, which were able to give us good solutions. Their products are shipped very fast and they work more efficiently.

Gobbs
Frequently Asked Question

Do you have any question?

Aging, as a natural process is identified by downregulation of energy production in mitochondria of various organs such as brain, adipose tissue, skin, liver, skeletal muscle and pancreas due to the depletion of NAD+ . NAD+ levels in the body decrease as a consequence of increasing NAD+ consuming enzymes when aging There are three different biosynthesis pathways to produce NAD+ in mammalian cells including de novo synthesis from tryptophan, salt and Preiss-Handler pathways. Among these three pathways, NMN is an interproduct by is involved in NAD+ biosynthesis through salt and Preiss-Handler pathways. The salvage pathway is the most efficient and the main route for the NAD+ biosynthesis, in which nicotinamide and 5-phosphoribosyl-1-pyrophosphate are converted to NMN with the enzyme of NAMPT followed by conjugation to ATP and conversion to NAD by NMNAT. Furthermore, NAD+ consuming enzymes are responsible for degradation of NAD+ and consequence nt formation of nicotinamide as a by-product.

The safety of NMN powder cannot be assessed since required clinical and toxicological studies have not been completed yet to establish the recommended safe levels for long term administration. Nevertheless, their safety and efficacy are uncertain and unreliable since most of them have not been back by Rigorous scientific preclinical and clinical testing. This issue has been arisen as manufacturers are hesitant to pay for research and clinical trials due to potential lower profit margin, and there is no authorizing agency to regulate NMN products because it is often product sold as functional food than heavily regulated therapeutic drug. Therefore, more strict approval process has been demanded by consumer advocacy groups requesting regulatory agencies to set standard and restrictions for marketing anti-aging health products, considering safety, health and wellbeing of N red besumers. a panacea for the elderly, because boosting NAD levels when not required may yield some detrimental effects. Therefore, the dose and frequency of NMN supplementation should be carefully prescribed depending on the type of age-related deficiency and all other confronting health conditions of the people. Other NAD precursors over have been studied to diverse age-related deficiencies and they are used for particular deficiencies, only after they are proven for effectiveness and safe to use. Therefore, the same principle should be applied to NMN as well

First, inspect the factory. After some screening, NMN companied that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NMN powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMN cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NMN powder produced by Bontac reach the purity of 99.9%. Finally, a professional test spectrum is needed to prove it. Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound ca n be preliminarily determined.

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How to Maintain NAD+ Homeostasis to Regulate Mitochondrial and Cardiac Function

1. Introduction Mitochondria are the center of energy metabolism in cardiomyocytes, which are necessary for maintaining normal myocardial contractility and cardiac function. Typically, the development of cardiovascular disease is usually accompanied by mitochondrial dysfunction. Impaired autophagy is known to cause mitochondrial dysfunction and heart failure, in part due to altered mitophagy and protein quality control. Notably, external replenishment of nicotinamide adenine dinucleotide (NAD+) precursors can enhance autophagy and mitochondrial quality control to maintain metabolic health, thereby regulate mitochondrial and cardiac function. 2. NAD+ metabolism in mitochondrial and cardiac function Cardiomyocytes accumulate NAD+ mostly within their mitochondria, where the bulk of cellular oxidation-reduction reactions occur. However, NAD+ is also present in the cytosol and nucleus, in which NAD+-derived metabolites and NAD+-dependent enzymes contribute to various cellular functions. 3. Mitochondrial and cardiac dysfunction induced by NAD+ deficiency Mitochondrial and cardiac dysfunction triggered by NAD+ deficiency is alleviated in cAtg3-KO mouse hearts post the administration of β-nicotinamide mononucleotide (NMN), as evidenced by the restoration of citrate synthase (CS) activity, partial normalization of ATP level and NPPB mRNA expression in cAtg3-KO mice as well as upregulation of ADP level in WT mouse hearts. Besides, NNMT inhibition can rescue mitochondrial and cardiac dysfunction in cAtg3-KO mice by restoring NAD+ level. 4. The impact of autophagic flux upon cardiac and mitochondrial function Autophagy is an intracellular degradation pathway that recycles subcellular components, playing a critical in modulating metabolic homeostasis. Autophagic flux, a central homeostatic mechanism that degrades materials toxic to cardiomyocytes, can mediate SQSTM1-NF-κB-NNMT signal transduction to control the cellular level of NAD+, thereby maintaining the mitochondrial and cardiac function.   5. Conclusion Autophagic flux may be a potential way to maintain the cellular level of NAD to regulate mitochondrial and cardiac fiunction. . Reference [1] Abdellatif M, Sedej S, Kroemer G. NAD+ Metabolism in Cardiac Health, Aging, and Disease. Circulation. 2021;144(22):1795-1817. doi:10.1161/CIRCULATIONAHA.121.056589 [2] Zhang Q, Li Z, Li Q, et al. Control of NAD+ homeostasis by autophagic flux modulates mitochondrial and cardiac function. EMBO J. Published online January 11, 2024. doi:10.1038/s44318-023-00009-w About BONTAC BONTAC has rich R&D experience and advanced technology in the biosynthesis of NAD and NMN. Bonzyme whole-enzymatic method is adopted, which is environmental-friendly, with no harmful solvent residues. The purity of products can reach up to 95%, which is benefited from the exclusive Bonpure seven-step purification technology. BONTAC has self-owned factories and has obtained a number of international certifications, where high quality and stable supply of products can be ensured. BONTAC has over 160 domestic and foreign patents, leading the industry of coenzyme and natural products. In the future, BONTAC will actively expand the international market, and work with global partners to promote the prosperous development of synthetic biology industry. In this era full of challenges and opportunities, BONTAC is confident to make greater contributions to the cause of human health. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC.  Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.

Ginsenoside Rg3: A Promising Therapeutic Agent for Traumatic Brain Injury

Introduction According to the 2017 Commission on Traumatic Brain Injury (TBI), TBI remains one of the top three causes of injury-related death and disability up to 2030. There are 50~60 million people suffering from TBI each year, with annual expenditure of about US$ 400 billion across the world. Among all common neurological disorders, TBI has the highest incidence and poses a substantial public health burden. Strikingly, ginsenoside Rg3, a critical active pharmaceutical component extracted from the traditional Chinese medicine ginseng, has been attested to be effective in reducing neuroinflammation and damage in hippocampal neurons of mice following TBI, showing great therapeutic potential in TBI. About TBI TBI primarily results from mechanical and sports-related injuries, leading to acute degenerative changes in the central nervous system. TBI patients are often accompanied with cognitive and motor deficits. Cognitive deficits arise from hippocampal neuron damage post-TBI, while motor deficits manifest as paresis, altered muscle tone, ataxia, and impaired coordination and balance after TBI. The efficacy and safety of ginsenoside Rg3 in TBI mice Ginsenoside Rg3 effectively enhances neurological and motor functions, reduces brain water content, and alleviates hippocampal neuronal neuroinflammation and damage in TBI mice. At doses of 1, 5, 10, and 20 µM, ginsenoside Rg3 is non-toxic to microglia. Notably, ginsenoside Rg3 at 20 µM shows the most prominent efficacy in TBI mice. The underlying mechanism of ginsenoside Rg3 in alleviating TBI The role of ginsenoside Rg3 in alleviating TBI may be realized by enhancing SIRT1 expression and inhibiting the NF-kB pathway. Specifically, ginsenoside Rg3 represses the key markers associated with the NF-kB pathway, as manifested by the reduced levels of p-IKBa, INOS, and nuclear P65 proteins in the hippocampus of TBI-afflicted mice. Apart from these, treatment with NAM, a SIRT1 inhibitor, counteracts the beneficial effects of ginsenoside Rg3 on neurological and motor function recovery, as well as its mitigating effects on hippocampal neuronal damage and inflammation in TBI-afflicted mice, hinting the involvement of SIRT1 in the alleviation of TBI with ginsenoside Rg3. Conclusion Collectively, ginsenoside Rg3 (20 µM) markedly ameliorates neurological and motor functions while attenuating neuroinflammation and hippocampal neuronal damage by regulating the SIRT1/NF-kB pathway in TBI mice. Reference [1] Liu X, Gu J, Wang C, et al. Ginsenoside Rg3 attenuates neuroinflammation and hippocampal neuronal damage after traumatic brain injury in mice by inactivating the NF-kB pathway via SIRT1 activation. Cell Cycle. Published online May 25, 2024. doi:10.1080/15384101.2024.2355008 [2] Maas AIR, Menon DK, Manley GT, et al. Traumatic brain injury: progress and challenges in prevention, clinical care, and research. Lancet Neurol. 2022;21(11):1004-1060. doi:10.1016/S1474-4422(22)00309-X BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). One-stop service for customized product solution is available in BONTAC. With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.

Empowering Metabolic Health with BONTAC's NAD-ER Grade Solutions

At BONTAC, we are at the forefront of the metabolism-boosting product industry, driven by our unwavering commitment to innovation and the pursuit of scientific excellence. Our focus on developing cutting-edge solutions has led us to the realm of NAD+, a crucial coenzyme that plays a pivotal role in maintaining optimal metabolic health. In this article, we delve into the importance of NAD+ and how our NAD-ER grade products can empower individuals to achieve their wellness goals. The Significance of NAD+ in Metabolic Processes Nicotinamide adenine dinucleotide, or NAD+, is a coenzyme that is essential for a wide range of metabolic processes within the human body. This dynamic molecule is involved in numerous cellular functions, including energy production, DNA repair, and the regulation of cellular aging. As we age, our natural NAD+ levels tend to decline, leading to a host of health challenges that can impact our overall metabolic well-being. Addressing the NAD+ Deficit with BONTAC's NAD-ER Grade Solutions At BONTAC, we recognized the pressing need for effective metabolism-boosting products that could address the NAD+ deficit. Our research and development team has dedicated countless hours to perfecting our NAD-ER grade solutions, which are designed to replenish and maintain optimal NAD+ levels within the body. Delivering Enhanced Bioavailability with ER-Grade NAD One of the key features of our NAD-ER grade products is their enhanced bioavailability. Through our proprietary formulation process, we have developed a slow-release mechanism that allows for a steadier and more efficient absorption of NAD+ into the bloodstream. This ensures that the coenzyme is readily available to support a wide range of metabolic processes, helping to maintain overall metabolic health. Unlocking the Power of NAD+ for Improved Energy and Cellular Function By supplementing with our NAD-ER grade products, individuals can experience a host of benefits that contribute to enhanced metabolic health. Increased NAD+ levels have been linked to improved energy production, as the coenzyme plays a crucial role in the conversion of food into usable energy for the body. Additionally, NAD+ is essential for the proper functioning of mitochondria, the "powerhouses" of our cells, further supporting overall metabolic efficiency. Promoting Healthy Aging and DNA Repair with ER-Grade NAD As we mentioned earlier, NAD+ levels tend to decline with age, which can lead to accelerated cellular aging and a higher risk of various health problems. Our NAD-ER grade products are designed to help counteract this natural decline, supporting the body's ability to repair damaged DNA and maintain cellular integrity. By promoting healthier aging, our metabolism-boosting products empower individuals to live fuller, more vibrant lives. Versatility and Applications of BONTAC's NAD-ER Grade Solutions The versatility of our NAD-ER grade products extends beyond personal health and wellness. These metabolic solutions have applications in a wide range of industries, including biopharmaceuticals, nutraceuticals, and even cosmeceuticals. Our team works closely with our partners to tailor our NAD-ER grade offerings to meet their specific needs, ensuring that they have access to the highest-quality, most effective metabolism-boosting products on the market. Conclusion At BONTAC, we are committed to leading the charge in the metabolism-boosting products industry. Our unwavering focus on innovation and the development of cutting-edge solutions has resulted in our NAD-ER grade products, which are poised to revolutionize the way individuals approach their metabolic health. By harnessing the power of NAD+, we are empowering our customers to achieve optimal energy, cellular function, and overall well-being. As we continue to push the boundaries of what's possible in the world of metabolism-boosting products, we remain dedicated to our mission of improving the lives of those we serve.

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