Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
NADH powder manufacturing method
The main methods of NMNH powder preparation include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme becomes the mainstream method owing to the advantages of pollution free, high level of purity and
BONTAC NMNH product features and advantages
1. "Bonzyme" Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder.
2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability.
3. Exclusive “Bonpure” seven-step purification technology, high purity (up to 99%) and stability of production of NMNH powder
4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder
5. Provide one-stop product solution customization service
NMNH is more potent than NMN
When applied to cultured cells, the NMNH is shown to be more efficient than NMN as it was able to “significantly increase NAD+ at a ten times lower concentration (5 µM) than that needed for NMN”. Moreover, NMNH shows to be more effective , as at 500 µM concentration, it achieved “an almost 10-fold increase in the NAD+ concentration, while NMN was only able to double NAD+ content in these cells, even at 1 mM concentration.”.
Interestingly, NMNH also appears to act quicker and has a longer-lasting effect compared to NMN. According to the authors, NMNH induces a “significant increase in NAD+ levels within 15 minutes”, and “NAD+ steadily increased for up to 6 hours and remained stable for 24 hours, while NMN reached its plateau after only 1 hour, most likely because the NMN recycling pathways to NAD+ had already become saturated.”.
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NADH is synthesized by the body and thus is not an essential nutrient. It does require the essential nutrient nicotinamide for its synthesis, and its role in energy production is certainly an essential one. In addition to its role in the mitochondrial electron transport chain, NADH is produced in the cytosol. The mitochondrial membrane is impermeable to NADH, and this permeability barrier effectively separates the cytoplasmic from the mitochondrial NADH pools. However, cytoplasmic NADH can be used for biologic energy production. This occurs when the malate-aspartate shuttle introduces reducing equivalents from NADH in the cytosol to the electron transport chain of the mitochondria. This shuttle mainly occurs in the liver and heart.
Nicotinamide adenine dinucleotide (NAD+ ) homeostasis is constantly compromised due to degradation by NAD+ -dependent enzymes. NAD+ replenishment by supplementation with the NAD+ precursors nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) can alleviate this imbalance. However, NMN and NR are limited by their mild effect on the cellular NAD+ pool and the need of high doses. Here, we report a synthesis method of a reduced form of NMN (NMNH), and identify this molecule as a new NAD+ precursor for the first time. We show that NMNH increases NAD+ levels to a much higher extent and faster than NMN or NR, and that it is metabolized through a different, NRK and NAMPT-independent, pathway. We also demonstrate that NMNH reduces damage and accelerates repair in renal tubular epithelial cells upon hypoxia/reoxygenation injury. Finally, we find that NMNH administration in mice causes a rapid and sustained NAD+ surge in whole blood, which is accompanied by increased NAD+ levels in liver, kidney, muscle, brain, brown adipose tissue, and heart, but not in white adipose tissue. Together, our data highlight NMNH as a new NAD+ precursor with therapeutic potential for acute kidney injury, confirm the existence of a novel pathway for the recycling of reduced NAD+ precursors and establish NMNH as a member of the new family of reduced NAD+ precursors.
First, inspect the factory. After some screening, NMNH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NMNH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMNH cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NMNH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.
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The Nuanced Role of NADPH in the Complex Landscape of Metabolic Disorders
1.Introduction Nicotinamide adenine dinucleotide phosphate hydrogen (NADPH), also known as reduced coenzyme II, is a critical cofactor in cellular antioxidant systems and lipid synthesis, which links insulin resistance and ferroptosis of pancreatic β cells in the context of metabolic disorders such as diabetes mellitus, playing a central role in maintaining metabolic homeostasis. 2. Biological role of NADPH NADPH functions as a coenzyme essential to cellular metabolism, playing pivotal roles in various critical biological processes, such as ROS scavenging, ROS production, fatty acid synthesis and cholesterol synthesis. 3. Biosynthetic pathway of NADPH Cellular production of NADPH is facilitated through several pathways, including the pentose phosphate pathway, the citric acid cycle, and fatty acid metabolism. The dynamic equilibrium between NADPH synthesis and consumption is essential for preserving cellular redox balance and enabling a host of biosynthetic reactions. 4. The role of NADPH in insulin secretion from pancreatic β-Cells Both redox reaction and metabolic signaling can modulate insulin secretion from pancreatic β-cells, where NADPH plays a central role. It can not only serves as a metabolic coupling factor, but also acts as a custodian of β-cell integrity, delicately managing the interplay between metabolic inputs and insulin output. 5. The interaction between insulin resistance and NADPH A substantial body of evidence reveals that NADPH is critical for the regulation of oxidative stress and inflammatory responses, the main contributors to the pathogenesis of insulin resistance. Specifically, NADPH is implicated in ROS production via NOX and is also utilized in the synthesis of new fatty acids, which contributes to the development of insulin resistance, particularly in the context of obesity-induced chronic inflammation. 6. The impact of NADPH upon the ferroptosis in the context of diabetes In pancreatic β cells, the elevated blood sugar and pro-inflammatory cytokines can trigger oxidative stress and iron accumulation to promote lipid peroxidation, thereby facilitating the ferroptosis. In return, the ferroptosis can reduce insulin secretion and beta cell mass, which is contributive to the progression of diabetes. In general, NADPH plays a dual role in ferroptosis. On the one hand, it can promote ROS generation via NOX. On the other hand, it can support antioxidant defense through glutathione regeneration. In the context of diabetes, NADPH may predominantly fuel processes leading to ferroptosis, mainly due to the enhanced activity and affinity of NOX, which however requires further research for verification. 7. Conclusion NADPH has a critical role in the complex landscape of metabolic disorders, particularly insulin resistance and ferroptosis. Regulating NADPH-related pathways may open up new opportunities for the treatment of metabolic disorders. Reference Moon, Dong-Oh. “NADPH Dynamics: Linking Insulin Resistance and β-Cells Ferroptosis in Diabetes Mellitus.” International journal of molecular sciences vol. 25,1 342. 26 Dec. 2023, doi:10.3390/ijms25010342 Production advantages and features of BONTAC NADPH BONTAC has rich R&D experience and advanced technology in the biosynthesis of NADPH. Bonzyme whole-enzymatic method is adopted, which is environmental-friendly, with no harmful solvent residues. The purity of NADPH can reach up to 95%, which is benefited from the exclusive Bonpure seven-step purification technology. BONTAC has self-owned factories and has obtained a number of international certifications, where high quality and stable supply of products can be ensured. BONTAC has four domestic and foreign NADPH patents, leading the industry. Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.
High Purity Nadh Powder Manufacturer: BONTAC’s Path to Excellence
In today's health industry, NADH (nicotinamide adenine dinucleotide), as an important coenzyme, is widely used to supplement energy and enhance immunity. It is crucial to choose high-quality, high-purity NADH powder. This article will introduce the leading High Purity Nadh Powder Manufacturer - BONTAC, and its path to excellence in the health industry. 1. BONTAC: Manufacturer of excellent quality As a well-known High Purity Nadh Powder Manufacturer, BONTAC is committed to providing high-quality, high-purity NADH powder. The company has advanced production equipment and technical teams to ensure that products strictly comply with quality standards during the manufacturing process and provide customers with the highest quality products. 2. Advantages of high-purity NADH powder The high purity NADH powder produced by BONTAC has many advantages. First of all, through advanced extraction and purification technology, the purity of the product is ensured to be over 99%, effectively improving its biological activity and absorption rate. Secondly, precise formula and strict quality control ensure the stability and safety of the product and reliably meet the needs of consumers. 3. Wide range of applications High-purity NADH powder has broad application prospects in the health industry. It can be used to produce various health products, nutritional products and functional foods, such as energy supplements, immune enhancers, etc. In addition, it is also widely used in the field of medicine as one of the important raw materials for treating diseases. 4. Commitment to quality and service first As a leading High Purity Nadh Powder Manufacturer, BONTAC always takes quality as its life and customer as the center. The company strictly implements the international standard quality management system to ensure that each batch of products meets the most stringent standards. At the same time, BONTAC also provides professional after-sales service to provide customers with technical support and solutions. Conclusion As a leading brand in the health industry, BONTAC has won the trust and recognition of customers with its excellent manufacturing technology, high-quality products and excellent services. Choosing BONTAC's high-purity NADH powder means choosing health, safety and reliability. In the future, BONTAC will continue to adhere to the concept of "quality first, service first" to create greater value for customers and help the development of the health industry.
What is Pure NMN Powder? Its Potential Benefits and 4 Basic Applications
Aging is an undeniable reality of life. It is a known fact that with increasing age, different body functions tend to decline. While we may not completely stop this decline, we can slow it down with pure NMN powder. NMN powder—Nicotinamide Mononucleotide—is a derivative of Vitamin B3 (Niacin). It is a potent anti-aging molecule that helps counter the effects of growing age. Moreover, it increases overall body energy, reducing tiredness. In simpler words, NMN is a total game changer in age vs. health combat! So, what is NMN powder, and how can you use it to maximize your health? Read on to find out all. What is Beta-Nicotinamide Mononucleotide (NMN)? NMN, or Beta-Nicotinamide Mononucleotide, is a precursor molecule of NAD+ (Nicotinamide Adenine Dinucleotide) in the body. Research has shown that NAD+ combines with particular molecules called sirtuins to enhance longevity, which is achieved by converting food molecules into energy packets that are later used to carry out bodily functions[1]. NAD+ is also a crucial component of the body's age cycle. It regulates cellular health by acting on anti-aging genes and turning them on and off to regulate metabolism. However, NAD+ only has limited body stores. Therefore, a decrease in NAD+ leads to aging. Pure NMN powder prevents this decline by complementing the NAD+ deficiency, ultimately leading to a better life expectancy. Potential Benefits of Pure NMN Powder David Sinclair, a Harvard professor of genetics, has been working on the benefits of pure NMN powder for aging for decades. According to David Sinclair's NMN research and existing studies, the role of NMN is that of an activator. Based on this role, NMN provides the following benefits to the body: 1. May Boost NAD+ Levels in the Body Acting as a moderator, NMN converts NAD into activated forms. It helps increase energy production in the body, making you feel energized. The activated NAD+ then performs vital functions of the body, like: * Reduced inflammation * Stress resistance * Maintaining circadian rhythms * DNA repairs * Boosting energy metabolism * Improving athletic performance 2. May Improve Metabolic Health and General Wellness Pure NMN powder raises NAD+ levels throughout your body. With a healthy diet and lifestyle, it may be helpful for old-age problems and chronic diseases, improving overall health. These might include: * Protect the cardiovascular and cerebrovascular * Prevent cancer * Regulates blood sugar * Help with weight loss * Improve sleeping * Prevent neurodegenerative diseases * Auxiliary hypolipidemic * Auxiliary hypoglycemic * Hearing and vision protectionPromote alcohol metabolism, hangover and protect the liver 3. May Offer Anti-Aging Effects NAD+ is a key player in our body's energy production and DNA repair processes. Pure NMN powder holds promise as a potential anti-aging agent by bolstering intracellular NAD+ levels. NMN may exert further anti-aging effects by enhancing mitochondrial function and potentially lengthening telomeres. Though the precise mechanisms underlying NMN's anti-aging properties are still under investigation, its potential to support cellular health and longevity by utilizing pure NMN powders effectively. Top 4 Applications of Pure NMN Powder Pure NMN can stand as a versatile supplement and is easily incorporated into our daily lives. Common dosage forms of NMN products may include capsules, tablets, granules, powder, candies, and beverages. With its potential benefits, pure NMN powder finds utility across multiple fields: 1. Health Care Products NMN supplements are used to treat a variety of health conditions. It is touted for its anti-aging properties and potential benefits for metabolism and overall health. Whether it's being used in an anti-aging supplement or a sleep aid, pure NMN powder holds promise for potentially slowing the effects of aging or enhancing sleep quality. 2. Cosmetic Raw Materials NMN also improves skin metabolism by boosting NAD+ production. It further helps to fight off skin problems, increases new regeneration, and creates a glow from within. It is widely used in some anti-aging skincare formulations and for moisturizing and repairing cosmetic products. 3. Functional Food Additives Pure NMN powder is also a functional food additive. It enhances mental concentration and physical vigor, particularly in situations demanding sustained energy. It is frequently found in energy drinks and various health foods like energy bars, gummies, and cereals. 4. Animal Health Last but not least, animal health also benefits from NMN powder. When used in medical treatments and animal feeds, they help boost overall physiological functions and promote vitality. It helps increase the overall life span of animals. BONTAC's Premium Quality Wholesale Pure NMN Powder The efficacy of NMN depends on the quality and purity of the product. Thus, always use high-quality and original NMN products for ideal results. BONTAC is a well-known brand among bio-engineered NMN suppliers. We are the raw material supplier for the NMN study of David Sinclair's team. At the same time, we are also the sole provider of raw materials for clinical trials in many well-known institutions in Japan and the United States. We are known for our premium-quality, pure NMN powder. Our NMN powder is white with no visible impurities. It has a unique smell and a balanced pH (3.0-4.0), offering up to 99.5% purity. Our product advantages include: * 21 domestic and international NMN patents and multiple international certifications * Exclusive “Bonpure” seven-step purification technology, high purity (up to 99.9%) and stability * “Bonzyme” whole-enzymatic method, no harmful solvent residues, environmental-friendly * Multiple in vivo studies show that BONTAC NMN is safe and effective * One-stop customized product solution * Self-owned factories, high quality and stable supply of products All these leading industrial technologies and advantages make BONTAC the best NMN supplier in the biotech industry. IFrame Source: https://www.youtube.com/watch?v=FYkkJfuwttg Final Thoughts NMN has great potential for skin, heart, gut, and aging concerns. When you choose BONTAC, expect nothing but pure NMN powder of unparalleled purity and quality. BONTAC also offers wholesale purchases of NMN powder bulk and a one-stop solution for large businesses. Contact us and get the latest information on product availability. References [1] Why Is Longevity Still a Scientific Mystery? Sirtuins—Past, Present and Future. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9821238/ (Accessed: 6 May 2024)