Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
NADH powder efficacy in health
1.Improved energy levels
Not only does NADH act as an important coenzyme in aerobic respiration, the [H] of NADH also carries a large amount of energy. Studies have demonstrated that extracellular use of NADH promotes increased intracellular ATP levels, suggesting that NADH penetrates cell membranes and elevates intracellular energy levels. On a macro level, exogenous supplementation of NADH helps to restore energy and enhance appetite. The increase in energy levels in the brain also helps to improve mental performance and sleep quality. NADH has been used overseas to improve chronic fatigue syndrome, increase exercise endurance, jet lag and other areas.
2.Cellular protection
NADH is a strong antioxidant that naturally occurs in cells and reacts with free radicals to inhibit lipid peroxidation, protecting mitochondrial membranes and mitochondrial function. It has been found that NADH can reduce oxidative stress in cells caused by various factors such as radiation, drugs, toxic substances, strenuous exercise and ischemia, thus protecting vascular endothelial cells, hepatocytes, cardiomyocytes, fibroblasts and neurons. Therefore, injectable or oral NADH is used clinically to improve cardiovascular and cerebrovascular diseases, and as an adjunct to cancer radiotherapy. Topical NADH has been shown to be effective in the treatment of rosacea and contact dermatitis.
3.Promotion of neurotransmitter production
Studies have shown that NADH significantly promotes the production of the neurotransmitter dopamine, a chemical signal that is essential for short-term memory, involuntary movements, muscle tone and spontaneous physical responses. It also mediates the release of growth hormone and determines muscle movement. Without sufficient dopamine, muscles become stiff. Parkinson's disease, for example, is caused in part by a disruption of dopamine synthesis in brain cells. Preliminary clinical data suggest that NADH can help improve the symptoms of Parkinson's disease [9]. NADH also promotes the biosynthesis of norepinephrine and serotonin, showing good potential for use in the relief of depression and Alzheimer's disease.
NADH manufacturing method
The main methods of NADH powder preparation from worldwide NADH manufacturers include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme become the mainstream method owing to the advantages of pollution free, high level of purity and stability.
BONTAC NADH product features and advantages
1、“Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder
2、Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NADH powder
3、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMN powder
4、Provide one-stop product solution customization service
User Reviews
What users say about BONTAC
Frequently Asked Question
Do you have any question?
1. Prevention and treatment of viral-induced inflammatory storms
Scientists have found after extensive research that neo-coronavirus has a mechanism similar to SARS virus to activate inflammatory vesicles NLRP3. and the activation of NLRP3 produces more inflammatory factors, generating excessive inflammation and thus triggering a deadly cytokine storm. This problem can be well addressed by NAD+, which inhibits the activity of NF-κB inflammatory pathway and NLRP3 inflammasome by increasing the activity of sirtuins (SIRT1, SIRT2 and SIRT3), thus preventing cytokine storm caused by excessive inflammation. Therefore, Sinclair and other scientists believe that increasing the concentration of NAD+ may play an important role in the prevention and treatment of neocoronavirus and other viral infections.
2. Restoration of virus-induced metabolic disorders
NAD+ is an essential coenzyme for many cellular energy metabolic pathways, present in every cell of the body, involved in thousands of reactions, and an important player in maintaining cellular viability. In the COVID-19 infection model, NAD+ and NMN supplementation was found to be effective in alleviating cell death and protecting the lung.
The action of supplemental NADH is unclear. Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer's disease, and minimizing physical disability and relieving depression in people with Parkinson's disease. Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes
First, inspect the factory. After some screening, NADH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NADH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMN cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NADH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.
Our updates and blog posts
The Regulatory Targets and Mechanisms of Ginsenoside Rh2 for NSCLC
Introduction In the presence of oxygen, tumors produce adenosine triphosphate (ATP) through glycolysis instead of mitochondrial oxidative phosphorylation, a phenomenon known as the “Warburg effect”. Aerobic glycolysis caused by an altered tumor microenvironment is an important factor contributing to malignant tumor progression. Ginsenoside Rh2 (Rh2) can specifically reverse the shift from tumor aerobic glycolysis to oxidative phosphorylation to modulate the metabolic behavior of non-small cell lung cancer (NSCLC), ultimately promoting the “benignization” of NSCLC. The suppressive impacts of Rh2 on the malignant progression of NSCLC Rh2 inhibits the proliferation, invasion and migration, while promoting the apoptosis of NSCLC cells. Meanwhile, Rh2 treatment represses tumor lymph angiogenesis, as manifested by the obviously reduced expression of CD31. Moreover, Rh2 hinders the metastasis of NSCLC by inhibiting the epithelial mesenchymal transition (EMT), as evidenced by the upregulation of E-cadherin and downregulation of N-cadherin in lung tissues post Rh2 treatment. Underlying targets and mechanisms of Rh2 against NSCLC Rh2 hampers NSCLC aerobic glycolytic capacity, including glucose uptake and lactate production, through the HIF1-α/PDK4 pathway. Specifically, Rh2 targets hypoxia-inducible factor HIF-1α to downregulate its expression, subsequently reducing the expression of PDK4, a pivotal enzyme during the glucose oxidation process. By this way, Rh2 further suppresses aerobic glycolysis, promotes mitochondrial aerobic oxidative process, and stimulates the production of reactive oxygen species (ROS), thereby promoting tumor cells to enter the normal apoptotic program. The efficacy of Rh2 combined with DCA in NSCLC Sodium dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDKs), has been commonly used in clinical practice as an anticancer drug targeting glycolysis, yet it has hepatotoxicity and neurotoxicity at high doses. Notably, the combination of Rh2 with DCA dramatically reverses the biometabolic behaviors of tumors, and further reduces the dosage of DCA, which decreases the toxicity of DCA, greatly increasing the drug efficacy. Conclusion Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in NSCLCs. It activates the apoptotic program of NSCLCs and exerts a potentiating and toxicity-reducing effect when used in combination with chemotherapeutic agents DCA, hinting its potential as an adjuvant against tumors. Reference Liu X, Li J, Huang Q, et al. Ginsenoside Rh2 shifts tumor metabolism from aerobic glycolysis to oxidative phosphorylation through regulating the HIF1-α/PDK4 axis in non-small cell lung cancer. Mol Med. 2024;30(1):56. Published 2024 Apr 26. doi:10.1186/s10020-024-00813-y BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). One-stop service for customized product solution is available in BONTAC. With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.
Step into Innovation with BONTAC at FBIF 2024
On June 25th ~ 27th 2024, Food and Beverage Innovation Forum (FBIF), one of the most influential event in Asia-Pacific, is going to held in National Exhibition and Convention Center, Shanghai, China. In the parallel exhibition, BONTAC will display its food-grade raw materials at Booth No. F503-1. About FBIF 2024 FBIF, renowned for its emphasis on innovation, is set to offer a premium and specialized exhibition and networking platform for the food industry. The upcoming FBIF 2024 spans over 62,000 square meters, with an anticipated participation of more than 900 exhibitors and 47,000 visitors. The exhibition will encompass a diverse range of sectors including functional foods, wines, plant-based foods, dairy products, snacks, condiments, original equipment manufacturing (OEM), ingredients, packaging, and marketing design. Up till now, FBIF has successfully been held nine times. BONTAC product catalog Products Grade Application Scope NMNH (β-Nicotinamide Mononucleotide, Reduced Form; CAS No.: 108347-85-9) Food grade Healthcare products NAD (Nicotinamide Adenine Dinucleotide; CAS No.: 53-84-9) Food grade; Cosmetic grade; Pharmaceutical grade; Industrial grade; Endotoxin-free grade Healthcare products; Biochemical diagnostic reagent; Industrial enzyme catalytic reaction NADH (Nicotinamide Adenine Dinucleotide, Reduced Form; CAS No.: 606-68-98) Food grade; Diagnostic reagent grade Healthcare products; Biochemical diagnostic reagent NR-CL (Nicotinamide Ribose Chloride; CAS No.: 23111-00-4) Food grade Healthcare products; Cosmetics; Medicine NR-Malate Food grade Healthcare products Ginsenoside Rh2 Food grade Healthcare products; Cosmetics; Beverage; Alcohol; Snack; Medicine; Functional food Ginsenoside Rg3 Stevioside RD Food grade; Pharmaceutical excipient grade Healthcare products; Beverage; Alcohol; Snack; Medicine; Functional food Stevioside RM Stevioside RA Varginsen® Ginseng Food grade; Cosmetic grade Medicine; Food; Cosmetics ori-cozyme®Yeast Ribonucleotide Food grade; Cosmetic grade Medicine; Food; Cosmetics Erythrothioneine Food grade; Cosmetic grade Food; Cosmetics Resveratrol Food grade Healthcare products; Cosmetics; Medicine Pyrroloquinoline quinone (PQQ) Food grade Healthcare products; Cosmetics; Medicine Coenzyme Q10 Food grade Healthcare products; Food ...... ...... ...... Future vision In the realm of food health, the future vision is being reshaped by the escalating consumer appetite for high-quality sustenance. Biosynthesis technology has emerged as a pivotal force, delivering a spectrum of food products that are both environmentally sustainable and nutritionally beneficial. Aligning with the ambitious target of achieving "carbon neutrality by 2060," BONTAC will continue to adhere to the mission of creating a healthier and better life through green low-carbon and high-value-added biosynthesis technology, with the innovation as the driving force, paving the way for a more sustainable future. BONTAC profile Bontac Bio-Engineering (Shenzhen) Co., Ltd. (also referred to as BONTAC) is a high-tech enterprise established in July 2012, with self-owned factories and 170+ invention patents. BONTAC integrates R&D, production and sales. There are six major series of product in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates. By virtue of the first whole-enzyme catalysis technology in China, BONTAC takes the industry lead in its niche field of coenzyme. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields.
Rare Ginsenosides: Potential Treatment for Hyperuricemia and Spermatozoa Damage
Introduction With changes in lifestyles and dietary structure, hyperuricemia shows an increasing prevalence year by year, which may become the second largest metabolic disease after diabetes mellitus, as well as the fourth most common chronic disease after hypertension, hyperglycemia, and hyperlipidemia. Recent research unravels that hyperuricemia is closely related to male infertility and affects semen quality. Long-term hyperuricemia, especially among younger individuals, may threaten the reproductive capacity of men at a reproductive age. Noteworthily, rare ginsenosides (RGs), the main active compounds in ginseng, have been proven to be effective in alleviating hyperuricemia and concomitant spermatozoa damage. About hyperuricemia Hyperuricemia is a metabolic disease caused by a purine metabolism disorder or insufficient excretion of uric acid. In traditional Chinese medicine (TCM), hyperuricemia is generally categorized as "gout" and "paralysis", which requires differential diagnosis and treatment. As described in the classic traditional Chinese medical text Shang Han Lun (On Cold Damage), ginseng can be used for hyperuricemia treatment. TCM Type of Hyperuricemia Treatment Endoretention of damp heat Clearing heat and dampness; promoting blood circulation to remove meridian obstruction Liver qi stagnation Soothing liver and relieving depression; regulating qi and relieving pain Spleen vacuity with damp encumbrance Invigorating spleen and removing dampness; promoting blood circulation to remove meridian obstruction Renal deficiency and blood stasis Invigorating kidney to replenish essence; promoting blood circulation to remove meridian obstruction Restoration of histopathological changes in the liver, kidney, and testes following treatment of RGs RGs counteract histopathological changes and alleviate the pathological lesions in the kidney and testes. No significant damage is observed in liver of mice with PO-induced hyperuricemia. Post RGS treatment, the renal tubular vacuolar degeneration, dilatation and swelling in potassium oxonate (PO)-induced hyperuricemia are mitigated. In addition to a slight increase in the thickness of the peritubular membrane, PO group shows a significant reduced trend towards the internal diameter of the seminiferous tubules as well as the number of germ cell layers in the tubular wall and mature spermatozoa. Yet, these trends are reversed. Meanwhile, the number of germ cell layers and sperm density are restored in the RGs group. Preventive and ameliorative effects of RGs in mice with PO-induced hyperuricemia RGS containing Rg3, Rk1, Rg6, and Rg5 could repress serum uric acid (UA) level, serum and hepatic xanthine oxidase (XO) activity, renal renal creatinine (CRE) and renal creatinine (CRE) levels, the accumulation of malondialdehyde (MDA) in the kidneys and the production of renal IL-1β, while promoting renal superoxide dismutase (SOD) and glutathione (GSH) activities in mice with PO-induced hyperuricemia. Moreover, RGs can improve sphingolipid metabolism, pyrimidine metabolism, and other metabolic pathways. RGs could increase gut microbial diversity, restore the Firmicutes/Bacteroidetes (F/B) ratio, and adjust the intestinal microbial balance. Remarkably, there is a correlation between differentially metabolites and the gut microbiota (Lactobacillus and Akkermansia). Conclusion RGs may be a candidate for the prevention and amelioration of hyperuricemia and concomitant sperm damage. On the one hand, RGs can alleviate PO-induced hyperuricemia by inhibiting XO activity, restoring renal function and regulating the intestinal flora balance. On the other hand, RGS can ameliorate the sperm damage associated with hyperuricemia by regulating sphingolipid metabolism, ameliorating renal oxidative stress, reducing inflammation, reversing renal injury, and repairing testicular tissue. Reference Ji X, Yu L, Han C, et al. Investigating the effects of rare ginsenosides on hyperuricemia and associated sperm damage via nontargeted metabolomics and gut microbiota. J Ethnopharmacol. 2024;332:118362. doi:10.1016/j.jep.2024.118362 BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 180 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). One-stop service for customized product solution is available in BONTAC. With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.