Features
Why Choose BONTAC?
Advantages of NMNH
NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity（up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service
Advantages of NADH
NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service
Advantages of NAD
NAD: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products
Advantages of MNM
NMN: 1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity（up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University
We Have The Best Solutions for Your Business
Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.
As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.
In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.
NAD Drip: Materials, NAD Powder, and Effectiveness Explained
NAD Drip therapy, also known as IV NAD therapy, is gaining attention for its potential health benefits. In this comprehensive guide, we delve into the essential components of NAD Drip, including the standards for NAD drip materials, the role of NAD powder in the process, and its effectiveness in promoting overall well-being.
- NAD Drip Materials Standards
- Quality Assurance in Material Selection:
For an effective NAD Drip, ensuring the highest standards in material selection is paramount. IV bags, tubing, and other equipment must meet stringent quality standards to guarantee patient safety and the proper administration of NAD.
- Sterilization and Safety Protocols:
Safety protocols, including sterilization, must be rigorously maintained. The materials involved in the NAD Drip process should adhere to industry best practices for cleanliness and patient safety.
- Professional Administration:
Trained healthcare professionals are essential for administering NAD Drip safely and effectively. Adequate training and certification of personnel are part of the materials standard.
- NAD Powder in NAD Drip
- The Role of NAD Powder:
NAD (Nicotinamide Adenine Dinucleotide) powder is a crucial component of NAD Drip therapy. It is a bioavailable form of NAD that is dissolved in a sterile saline solution for intravenous infusion.
- Purity and Quality:
The quality and purity of NAD powder are vital. The best NAD powder is produced using high-quality raw materials and rigorous manufacturing standards to ensure the absence of impurities or contaminants.
- Dosage and Customization:
NAD Drip therapy can be tailored to individual needs through the precise control of NAD powder dosage. Customized dosages can be formulated based on a patient's specific requirements.
- NAD Drip Effectiveness
- Boosting Cellular Energy:
NAD Drip therapy is believed to enhance cellular energy production by increasing NAD levels in the body. This has potential benefits for overall vitality and performance.
- Anti-Aging Properties:
NAD Drip therapy is also associated with potential anti-aging effects, as NAD plays a key role in DNA repair and cell rejuvenation.
- Support for Wellness:
Many individuals turn to NAD Drip therapy to support general wellness, particularly in conditions related to fatigue, oxidative stress, and age-related health concerns.
NAD Drip therapy is a promising avenue for those seeking to optimize their well-being. Ensuring the highest standards for NAD Drip materials, the quality of NAD powder, and understanding its potential effectiveness is essential for a safe and successful therapy experience.
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Extraordinary Merits of Ultrasensitive ELISA with Thio-NAD Cycling in Determining Dengue NS1 Protein
1. Introduction Dengue fever is an acute infectious disease caused by the Dengue virus through the bite of an infected Aedes species (Ae. aegypti or Ae. albopictus) mosquito, with the main symptoms such as high fever, dizziness, headache, rash and severe pains (eye, muscle, joint, or bone pain), etc. This disease is widely prevalent in tropical and subtropical climates. An estimated 100 to 400 million people are infected each year, where over 80% are usually mild and asymptomatic. Nonetheless, severe Dengue fever can increase the risk of death if not treated properly. Thus, early diagnosis of this disease is significant to its timely treatment. Noteworthily, non-structural protein 1 (NS1), a highly conserved glycoprotein, is chiefly secreted during the infection of Dengue virus, which is intensively deemed as the main pathogenesis factor of Dengue fever. Hence, NSI is generally used as a biomarker for the early detection of this disease. In this study, a sandwich enzyme-linked immunosorbent assay (ELISA) in combination with the thio nicotinamide adenine dinucleotide (thio-NAD/S-NAD) cycling method (hereafter termed ultrasensitive ELISA) is utilized to detect NSI, followed by the comparison with NAAT to confirm its detection accuracy. 2. Advantages and disadvantages of traditional detection methods for Dengue fever At present, there are four main detection methods for Dengue fever. Viral isolation and identification have high specificity but are time-consuming, taking at least 5 days. The rapid antigen test is the fastest and most cost-efficient among the other methods, but the sensitivity and specificity are relatively low. Serologic test based on IgM and IgG is limited by the number of days of infection, as the test must be delayed until the level of antibodies rises to a detectable level. In clinic, NAAT is often applied to determine Dengue fever by dirt of its high sensitivity and specificity. However, this method is expensive, laborious, and prone to false positivity, which must be conducted by the trained personnel. To overcome the disadvantages of these methods, a new detection method ultrasensitive ELISA is applied in this study. 3. Workflow of ultrasensitive ELISA with thio-NAD cycling A pair of antibodies is used for capturing the NS1 protein in the sandwich ELISA, and alkaline phosphatase is labeled on the secondary antibody. Aside from the antibodies, an androsterone derivative, 3α-hydroxysteroid dehydrogenase, thio-NAD, and NADH are used to construct the thio-NAD enzyme cycling system. During the thio-NAD cycling reaction, thio-NADH constantly accumulated in a triangular number fashion and could be directly measured at an absorbance of 405 nm. 4. The comparison of ultrasensitive ELISA and NAAT in the detection of Dengue NS1 Protein In NAAT, 60 specimens are dengue-positive, and 25 are dengue-negative. The NAAT cycling threshold (CT) value of those dengue-positive specimens ranged from 12.42 to 31.41. In the ultrasensitive ELISA, 59 specimens are correspondingly positive to the NAAT results, whereas 25 specimens are completely correspondingly negative to the NAAT results. Compared with NAAT, the sensitivity and specificity of the ultrasensitive ELISA are 98.3% and 100%, respectively (Table 2). Of 60 NAAT-confirmed dengue-positive patient specimens, only 1 specimen is negative in the ultrasensitive ELISA. The NAAT data showed that the specimen is a type 4 DENV infection case with a CT value of 21.59. The results of the ultrasensitive ELISA are in almost perfect agreement with the NAAT results, with a kappa value of 0.972 (95% CI: 0.917-1.0). 5. Conclusion Ultrasensitive ELISA method is easy to perform and requires no professional trainees to operate. The detection can be started immediately after receiving a small sample. It is particularly suitable for the early detection of Dengue disease in low-income countries. Reference Chen, Po-Kai et al. “Advanced Detection Method for Dengue NS1 Protein Using Ultrasensitive ELISA with Thio-NAD Cycling.” Viruses vol. 15,9 1894. 8 Sep. 2023, doi:10.3390/v15091894 Product advantages and features of BONTAC Thio-NAD/S-NAD BONTAC is one of the few enterprises in China that can produce Thio-NAD, with “Bonzyme” Whole-enzymatic method (environmental-friendly; no harmful solvent residues) and unique “Bonpure” seven-step purification technology. BONTAC intergrates R&D, production and sale, with self-owned factories and a number of international certifications to ensure high quality and stable supply of products. Disclaimer BONTAC shall hold no responsibility for any claims arising directly or indirectly from your reliance on the information and material on this website.
Deciphering Another Mechanism of Action for NMN Administration: Improving Lysosomal Ferroptosis to Prevent Heart Failure
1. Introduction Heart failure is a serious condition in the development of cardiovascular disease. In particular, diastolic heart failure, as one of the most common manifestations of heart failure in the elderly, has always been viewed as a classic aging-related terminal illness due to its high prevalence and lack of effective treatment. Nicotinamide mononucleotide (NMN) raises the hope for the treatment of this illness. NMN can restore the functions of heart and blood vessels, protect the heart from damage after a heart attack, prevent heart failure by promoting the health of the mitochondria, and restore cardiovascular, cognitive, and metabolic decline. This study is dedicated to deciphering another mechanism of action for NMN administration, namely improving lysosomal ferroptosis to prevent heart failure. 2. The key pathogenesis of diastolic heart failure The effect of NMN on improving cardiac function is mainly realized by elevating the level of myocardial nicotinamide adenine dinucleotide (NAD+), an important coenzyme in the tricarboxylic acid cycle. The mitochondrial dysfunction and decreased ability of NAD+ biosynthesis are the key pathogenesis of diastolic heart failure. 3. Restoration of lysosomal function and autophagic function by NMN administration Lysosomal function is impaired owing to decreased NAD+ biosynthesis in vivo. NMN administration improves lysosomal function and activates amino acid metabolism in the mice with cardiomyocyte-specific knockout of p32 (p32cKO), yet barely affects the lysosomal morphology. Additionally, NMN administration improves the degradation mechanism of autophagy, as evidenced by the restoration of autophagic function post NMN administration. 4. The detailed mechanism of action for NMN administration on heart failure NMN administration does not restore functional mitochondrial damage caused by the inhibition of mitochondrial translation. These findings suggest that NMN administration improves heart failure by improving lysosomal function without improving mitochondrial function. 5. The involvement of ferroptosis in heart-specific mitochondrial translation defect The suppression of ferroptosis ameliorates heart failure. The expression levels of ferroptosis-related factors (Chac1, GPX4, and Ho1) are also diminished by NMN, indicating that ferroptosis in the p32cKO heart is improved by NMN administration. 6. The improvement of mitochondrial dysfunction-induced ferroptosis by NMN administration The ferroptosis is induced in the p32 knockdown cells, as attested by the mitochondrial translation defect and the downregulation of intracellular NAD+ and NADH levels. The induction of ferroptosis in lysosome is closely related to the amount of NAD+ biosynthesis. When intracellular NAD+ level is lowered, the intracellular iron deposition and lipid peroxide are induced, which however are ameliorated by NMN administration. 7. Conclusion Mechanically, NMN administration can prevent heart failure by improving lysosomal ferroptosis, opening up new insight for the treatment of this illness. Reference Yagi, Mikako et al. “Improving lysosomal ferroptosis with NMN administration protects against heart failure.” Life science alliance vol. 6,12 e202302116. 4 Oct. 2023, doi:10.26508/lsa.202302116 BONTAC NMN product features and advantages * “Bonzyme” Whole-enzymatic method (environmental-friendly; no harmful solvent residues) * Exclusive “Bonpure” seven-step purification technology, with high purity (up to 99.9%) and stability * Industrial leading technology: 15 domestic and international NMN patents * Self-owned factories and a number of international certifications to ensure high quality and stable supply of products * One-stop customized service for product solution * NMN raw material supplier of famous David Sinclair team of Harvard University Disclaimer This article is based on the reference in the academic journal. The relevant information is provide for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC.
Hi & Fi Asia-China 2022
The 23rd Healthy Natural Raw materials, food ingredients China Exhibition opened in Shanghai National Convention and Exhibition Center Bangtai Biological with the third generation of total enzyme catalytic technology C position debut to carry out a three-day total enzyme catalytic high purity NMN raw materials debut tour booth number: 41H40. Hi & Fi Asia-China