A brief introduction to nadh manufacturer | BONTAC

A brief introduction to nadh manufacturer | BONTAC

NADH (Beta-Nicotinamide adenine dinucleotide) is a chemical compound that is the reduced form of nicotinamide adenine dinucleotide, reduced coenzyme I. N refers to nicotinamide, A to adenine and D to dinucleotide. NADH is also known as a mitochondrial element because it is mainly involved in the metabolism of substances and energy in cells, is produced in the citric acid cycle in glycolysis and cellular respiration, and acts as a carrier of biohydrogen and an electron donor, transferring energy to supply ATP synthesis through the oxidative phosphorylation process in the inner mitochondrial membrane. Theoretically, one molecule of NADH releases energy to synthesize three molecules of ATP. NADH plays an important role in maintaining cell growth, differentiation and energy metabolism as well as cell protection. NADH is produced in the citric acid cycle in glycolysis and cellular respiration. the NADH molecule is a control marker in the energy production chain in mitochondria. Monitoring the redox state of NADH is the best parameter to characterize mitochondrial function in vivo. UV light can excite NADH in mitochondria to produce fluorescence and is used to monitor mitochondrial function.
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Advantages of NMNH

NMNH: 1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2. Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3. Exclusive “Bonpure” seven-step purification technology, high purity(up to 99%) and stability of production of NMNH powder 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5. Provide one-stop product solution customization service

Advantages of NADH

NADH: 1. Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3. Special patented process crystal form, higher stability 4. Obtained a number of international certifications to ensure high quality 5. 8 domestic and foreign NADH patents, leading the industry 6. Provide one-stop product solution customization service

Advantages of NAD

NAD:  1. “Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Stable supplier of 1000+ enterprises around the world 3. Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4. Freeze drying technology to ensure stable product quality 5. Unique crystal technology, higher product solubility 6. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products

Advantages of MNM

NMN:  1. “Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2. Exclusive“Bonpure”seven-step purification technology, high purity(up to 99.9%) and stability 3. Industrial leading technology: 15 domestic and international NMN patents 4. Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5. Multiple in vivo studies show that Bontac NMN is safe and effective 6. Provide one-stop product solution customization service 7. NMN raw material supplier of famous David Sinclair team of Harvard University

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Bontac Bio-Engineering (Shenzhen) Co., Ltd. (hereafter referred to as BONTAC) is a high-tech enterprise established in July 2012. BONTAC integrates R&D, production and sales, with enzyme catalysis technology as the core and coenzyme and natural products as main products. There are six major series of products in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates.

As the leader of the global NMN industry, BONTAC has the first whole-enzyme catalysis technology in China. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields. BONTAC adheres to independent innovation, with more than 170 invention patents. Different from the traditional chemical synthesis and fermentation industry, BONTAC has advantages of green low-carbon and high-value-added biosynthesis technology. What’s more, BONTAC has established the first coenzyme engineering technology research center at the provincial level in China which also is the sole in Guangdong Province.

In the future, BONTAC will focus on its advantages of green, low-carbon and high-value-added biosynthesis technology, and build ecological relationship with academia as well as upstream/downstream partners, continuously leading the synthetic biological industry and creating a better life for human beings.

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NADH manufacturing method

The main methods of NADH powder preparation from worldwide NADH manufacturers include extraction, fermentation, fortification, biosynthesis and organic matter synthesis. Compared with other preparations, the whole enzyme become the mainstream method owing to the advantages of pollution free, high level of purity and stability.  

NADH manufacturing method

BONTAC NADH product features and advantages

1、“Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder

2、Exclusive “Bonpure” seven-step purification technology, high purity(up to 99%) and stability of production of NADH powder

3、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMN powder  

4、Provide one-stop product solution customization service

BONTAC NADH product features and advantages

NADH powder efficacy in health

1.Improved energy levels
Not only does NADH act as an important coenzyme in aerobic respiration, the [H] of NADH also carries a large amount of energy. Studies have demonstrated that extracellular use of NADH promotes increased intracellular ATP levels, suggesting that NADH penetrates cell membranes and elevates intracellular energy levels. On a macro level, exogenous supplementation of NADH helps to restore energy and enhance appetite. The increase in energy levels in the brain also helps to improve mental performance and sleep quality. NADH has been used overseas to improve chronic fatigue syndrome, increase exercise endurance, jet lag and other areas.
2.Cellular protection
NADH is a strong antioxidant that naturally occurs in cells and reacts with free radicals to inhibit lipid peroxidation, protecting mitochondrial membranes and mitochondrial function. It has been found that NADH can reduce oxidative stress in cells caused by various factors such as radiation, drugs, toxic substances, strenuous exercise and ischemia, thus protecting vascular endothelial cells, hepatocytes, cardiomyocytes, fibroblasts and neurons. Therefore, injectable or oral NADH is used clinically to improve cardiovascular and cerebrovascular diseases, and as an adjunct to cancer radiotherapy. Topical NADH has been shown to be effective in the treatment of rosacea and contact dermatitis.
3.Promotion of neurotransmitter production
Studies have shown that NADH significantly promotes the production of the neurotransmitter dopamine, a chemical signal that is essential for short-term memory, involuntary movements, muscle tone and spontaneous physical responses. It also mediates the release of growth hormone and determines muscle movement. Without sufficient dopamine, muscles become stiff. Parkinson's disease, for example, is caused in part by a disruption of dopamine synthesis in brain cells. Preliminary clinical data suggest that NADH can help improve the symptoms of Parkinson's disease [9]. NADH also promotes the biosynthesis of norepinephrine and serotonin, showing good potential for use in the relief of depression and Alzheimer's disease.

NADH powder efficacy in health
User Reviews

What users say about BONTAC

BONTAC is a reliable partner that we have been working with for many years. The purity of their coenzyme is very high. Their COA can achieve relatively high test results.

Front

I discovered BONTAC in 2014 because David's article in cell about NAD and NMN related showed that he used BONTAC's NMN for his experimental material. Then we found them in China. After so many years of cooperation, I think it is a very good company.

Hanks

I think green, healthy and high purity are the advantages of BONTAC's products compared with others. I still work with them to this day.

Phillip

In 2017, we chose BONTAC's coenzyme, during which our team encountered many technical problems and consulted their technical team, which were able to give us good solutions. Their products are shipped very fast and they work more efficiently.

Gobbs
Frequently Asked Question

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1.    Prevention and treatment of viral-induced inflammatory storms
Scientists have found after extensive research that neo-coronavirus has a mechanism similar to SARS virus to activate inflammatory vesicles NLRP3. and the activation of NLRP3 produces more inflammatory factors, generating excessive inflammation and thus triggering a deadly cytokine storm. This problem can be well addressed by NAD+, which inhibits the activity of NF-κB inflammatory pathway and NLRP3 inflammasome by increasing the activity of sirtuins (SIRT1, SIRT2 and SIRT3), thus preventing cytokine storm caused by excessive inflammation. Therefore, Sinclair and other scientists believe that increasing the concentration of NAD+ may play an important role in the prevention and treatment of neocoronavirus and other viral infections.
2.    Restoration of virus-induced metabolic disorders
NAD+ is an essential coenzyme for many cellular energy metabolic pathways, present in every cell of the body, involved in thousands of reactions, and an important player in maintaining cellular viability. In the COVID-19 infection model, NAD+ and NMN supplementation was found to be effective in alleviating cell death and protecting the lung.

The action of supplemental NADH is unclear. Oral NADH supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia. Researchers are also studying the value of NADH supplements for improving mental function in people with Alzheimer's disease, and minimizing physical disability and relieving depression in people with Parkinson's disease. Some healthy individuals also take NADH supplements orally to improve concentration and memory capacity, as well as to increase athletic endurance. However, to date there have been no published studies to indicate that using NADH is in any way effective or safe for these purposes

First, inspect the factory. After some screening, NADH companies that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NADH powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NMN powder. If high purity NMN cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NADH powder produced by Bontac reach the purity of 99%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.

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Tight Connection of NADP+/NADPH Balance with Cardiovascular Pathologies

Introduction Cardiovascular diseases (CVD) poses huge economic burden and great threat to the life of patients, even surpassing Alzheimer's disease and diabetes. 17.9 million people in the world die from CVD, with indirect treatment costs of $237 billion per year, which are projected to increase to $368 billion by 2035. It has been reported that the deficiency or imbalance of oxidized nicotinamide adenine dinucleotide phosphate (NADP+)/reduced nicotinamide adenine dinucleotide phosphate (NADPH) redox couple has been linked to a variety of pathological conditions including CVD. NADP(H) redox couple as cofactor/electron carrier in cardiommyocytes NADPH is an essential cofactor of glutathione reductase (GR) and thioredoxin reductase (TRs) in cardiommyocytes, with a crucial role in maintaining cellular redox homeostasis and energy metabolism. GR catalyzes the recycling of Glutathion (GSH) from oxidized glutathione (GSSG), and TRs reduces oxidized Trx-S2 into Trx-(SH)2. Simultaneously, both enzymes require NADPH as an electron donor and oxidize it to NADP+. Once O2•− is formed, for example, from NOXs in the cytosol and from mitochondrial electron transport chain (ETC), cytosolic CuZnSOD and mitochondrial MnSOD will reduce it to H2O2. GSH can be used by glutathione peroxidase (GPx) to reduce H2O2 further to water. Trx-(SH)2 provides reducing equivalents for Prx in the removal of H2O2. The connection of NADP(H) with cardiovascular pathologies NADP(H) plays a dual role in cardiovascular pathologies. On the one hand, the reduced NADPH can result in significant antioxidant deficiencies and intracellular accumulation of free radicals, which triggers lipid peroxidation, inflammation, and vascular dysfunction, ultimately exacerbating the course of atherosclerosisoxidase. On the other hand, high NADPH level can give rise to myocardial injury by inducing reductive stress and enhancing reactive oxygen species (ROS) production. Conclusion Changes in cellular NADP(H) content affect the intermediary metabolism of cardiac function, especially in diseased myocardium. Maintaining the balance between NADP+ and NADPH in cardiommyocytes is critically important for the treatment of CVD. Either deficiency or excess NADP(H) levels can lead to imbalances in cellular redox state and metabolic homeostasis, resulting in energy stress, redox stress, and ultimately disease state. NADP(H) has an important therapeutic value in CVD. Reference Sun Y, Wu D, Hu Q. NADP+/NADPH in Metabolism and its Relation to Cardiovascular Pathologies. Curr Med Chem. Published online February 16, 2024. doi:10.2174/0109298673275187231121054541 BONTAC NADP(H) BONTAC has dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team consisting of Doctors and Masters. BONTAC has rich R&D experience and advanced technology in the biosynthesis of NADP(H). Bonzyme whole-enzymatic method is adopted, which is environmental-friendly, with no harmful solvent residues. The purity of NADP and NADPH can reach up to 95% and 98%, respectively, which is benefited from the exclusive Bonpure seven-step purification technology. BONTAC has self-owned factories and has obtained a number of international certifications, where high quality and stable supply of products can be ensured. BONTAC has four domestic and foreign NADPH patents, leading the industry. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be held responsible or liable in any way for any claims, damages, losses, expenses, costs or liabilities whatsoever (including, without limitation, any direct or indirect damages for loss of profits, business interruption or loss of information) resulting or arising directly or indirectly from your reliance on the information and material on this website.

Step into Innovation with BONTAC at FBIF 2024

On June 25th ~ 27th 2024, Food and Beverage Innovation Forum (FBIF), one of the most influential event in Asia-Pacific, is going to held in National Exhibition and Convention Center, Shanghai, China. In the parallel exhibition, BONTAC will display its food-grade raw materials at Booth No. F503-1. About FBIF 2024 FBIF, renowned for its emphasis on innovation, is set to offer a premium and specialized exhibition and networking platform for the food industry. The upcoming FBIF 2024 spans over 62,000 square meters, with an anticipated participation of more than 900 exhibitors and 47,000 visitors. The exhibition will encompass a diverse range of sectors including functional foods, wines, plant-based foods, dairy products, snacks, condiments, original equipment manufacturing (OEM), ingredients, packaging, and marketing design. Up till now, FBIF has successfully been held nine times. BONTAC product catalog Products Grade Application Scope NMNH (β-Nicotinamide Mononucleotide, Reduced Form; CAS No.: 108347-85-9) Food grade Healthcare products NAD (Nicotinamide Adenine Dinucleotide; CAS No.: 53-84-9) Food grade; Cosmetic grade; Pharmaceutical grade; Industrial grade; Endotoxin-free grade Healthcare products; Biochemical diagnostic reagent; Industrial enzyme catalytic reaction NADH (Nicotinamide Adenine Dinucleotide, Reduced Form; CAS No.: 606-68-98) Food grade; Diagnostic reagent grade Healthcare products; Biochemical diagnostic reagent NR-CL (Nicotinamide Ribose Chloride; CAS No.: 23111-00-4) Food grade Healthcare products; Cosmetics; Medicine NR-Malate Food grade Healthcare products Ginsenoside Rh2 Food grade Healthcare products; Cosmetics; Beverage; Alcohol; Snack; Medicine; Functional food Ginsenoside Rg3 Stevioside RD Food grade; Pharmaceutical excipient grade Healthcare products; Beverage; Alcohol; Snack; Medicine; Functional food Stevioside RM Stevioside RA Varginsen® Ginseng Food grade; Cosmetic grade Medicine; Food; Cosmetics ori-cozyme®Yeast Ribonucleotide Food grade; Cosmetic grade Medicine; Food; Cosmetics Erythrothioneine Food grade; Cosmetic grade Food; Cosmetics Resveratrol Food grade Healthcare products; Cosmetics; Medicine Pyrroloquinoline quinone (PQQ) Food grade Healthcare products; Cosmetics; Medicine Coenzyme Q10 Food grade Healthcare products; Food ...... ...... ...... Future vision In the realm of food health, the future vision is being reshaped by the escalating consumer appetite for high-quality sustenance. Biosynthesis technology has emerged as a pivotal force, delivering a spectrum of food products that are both environmentally sustainable and nutritionally beneficial. Aligning with the ambitious target of achieving "carbon neutrality by 2060," BONTAC will continue to adhere to the mission of creating a healthier and better life through green low-carbon and high-value-added biosynthesis technology, with the innovation as the driving force, paving the way for a more sustainable future. BONTAC profile Bontac Bio-Engineering (Shenzhen) Co., Ltd. (also referred to as BONTAC) is a high-tech enterprise established in July 2012, with self-owned factories and 170+ invention patents. BONTAC integrates R&D, production and sales. There are six major series of product in BONTAC, involving coenzymes, natural products, sugar substitutes, cosmetics, dietary supplements and medical intermediates. By virtue of the first whole-enzyme catalysis technology in China, BONTAC takes the industry lead in its niche field of coenzyme. Our coenzyme products are widely used in health industry, medical & beauty, green agriculture, biomedicine and other fields.

Rh2 and Ca(OH)2 Combo: Promising Treatment for Root Canal Infections

Introduction Apical periodontitis, an inflammatory disease affecting tooth apex tissues, is triggered by oral pathogens infecting the root canal. One of the main reason for endodontic treatment failure is Enterococcus (E.) faecalis, a pathogenic bacterium that has extremely high tolerance to the most often used root canal dressing calcium hydroxide (Ca(OH)2). Ginsenoside Rh2, a Chinese herbal extract, has been affirmed to possess anti-microbial properties and synergistic activities. The combination of Rh2 with Ca(OH)2 appears to be a potential alternative to root canal treatment. About E. faecalis E. faecalis is a facultative anaerobic gram-positive bacterium, which has been deemed as the main pathogenic factor of refractory periapical infections. This bacterium can survive for a long time by forming a biofilm with very strong adhesion in a hostile environment, and is resistant to the mechanical cleaning and the medications for root canal disinfection. The synergistic antibacterial activities of Rh2 and Ca(OH)2 against E. faecalis. Rh2 has the potential to enhance the ability of Ca(OH)2 to eradicate E. faecalis and its biofilms in root canals by disrupting the cell membrane and inhibiting the proton transport system on the bacterial surface. The removal of mature bioflims by Rh2 is mainly achieved by removing extracellular polysaccharides and inhibiting bacterial activity. Specifically, Rh2 significantly inhibits H+/K+-ATPase activity of E. faecalis with increasing drug concentration, thus inhibiting the exocytosis of −OH from Ca(OH)2. Strikingly, neither Rh2 nor its combination with Ca(OH)2 shows toxicity to L929 cells at effective antimicrobial activity concentrations. Conclusion Rh2 is a phytochemical substance, with the merits of low cytotoxicity, high efficiency and reproducibility, stable quality, and enhancement of the efficacy of antagonistic drugs. Ginsenoside Rh2 and Ca(OH)2 exert a synergistic antibacterial effect on E. faecalis, providing novel insights into the development of root canal treatment drugs. Reference Liu C, Li Y, Li Y, Li Z, Han G. Synergistic antibacterial effect of ginsenoside Rh2 and Ca(OH)2 on Enterococcus faecalis. Odontology. Published online May 19, 2024. doi:10.1007/s10266-024-00951-z BONTAC Ginsenosides BONTAC has been dedicated to the R&D, manufacture and sale of raw materials for coenzyme and natural products since 2012, with self-owned factories, over 170 global patents as well as strong R&D team. BONTAC has rich R&D experience and advanced technology in the biosynthesis of rare ginsenosides Rh2/Rg3, with pure raw materials, higher conversion rate and higher content (up to 99%). One-stop service for customized product solution is available in BONTAC. With unique Bonzyme enzymatic synthesis technology, both S-type and R-type isomers can be accurately synthesized here, with stronger activity and precise targeting action. Our products are subjected to strict third-party self-inspection, which are worth of trustworthy. Disclaimer This article is based on the reference in the academic journal. The relevant information is provided for sharing and learning purposes only, and does not represent any medical advice purposes. If there is any infringement, please contact the author for deletion. The views expressed in this article do not represent the position of BONTAC. Under no circumstances will BONTAC be responsible for any claims, damages, losses, expenses, or costs arising directly or indirectly from your reliance on the information and material on this website.

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