nad manufacturer | What is NAD

nad manufacturer | What is NAD

NAD refers to  Nicotinamide adenine dinucleotide, found in all living cells, NAD with the CAS NO. of 53-84-9 and the chemical  formula of C21H27N7O14P2 is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other nicotinamide NAD exists in two forms: an oxidized and reduced form, abbreviated as NAD+ and NADH (H for hydrogen), respectively.
In metabolism, nicotinamide adenine dinucleotide is involved in redox reactions, carrying electrons from one reaction to another. The cofactor is, therefore, found in two forms in cells: NAD+ is an oxidizing agent – it accepts electrons from other molecules and becomes reduced. This reaction, also with H+, forms NADH, which can then be used as a reducing agent to donate electrons. These electron transfer reactions are the main function of NAD. However, it is also used in other cellular processes, most notably as a substrate of enzymes in adding or removing chemical groups to or from, respectively, proteins, in posttranslational modifications. Because of the importance of these functions, the enzymes involved in NAD metabolism are targets for drug discovery.
In organisms, NAD can be synthesized from simple building-blocks (de novo) from either tryptophan or aspartic acid, each a case of an amino acid; alternatively, more complex components of the coenzymes are taken up from nutritive compounds such as niacin; similar compounds are produced by reactions that break down the structure of NAD, providing a salvage pathway that “recycles” them back into their respective active form.
Some NAD is converted into the coenzyme nicotinamide adenine dinucleotide phosphate (NADP); its chemistry largely parallels that of NAD, though predominantly its role is as a cofactor in anabolic metabolism.  
In general, there are three main manufacture methods for NAD preparation utilized by NAD manufacturers in the world such as chemical or enzymatic synthesis, and fermentation biosynthesis. And at present, the NAD manufacturers are located worldwide including China, America, Japan and German.

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Advantages of NMNH

NMNH: 1、“Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder. 2、Bontac is a very first manufacture in the world to produce the NMNH powder on the level of high purity, stability. 3、Exclusive “Bonpure” seven-step purification technology, high purity(up to 99%) and stability of production of NMNH powder 4、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NMNH powder 5、Provide one-stop product solution customization service

Advantages of NADH

NADH: 1、Bonzyme whole-enzymatic method, environmental-friendly, no harmful solvent residues 2、Exclusive Bonpure seven-step purification technology, purity up higher than 98 % 3、Special patented process crystal form, higher stability 4、Obtained a number of international certifications to ensure high quality 5、8 domestic and foreign NADH patents, leading the industry 6、Provide one-stop product solution customization service

Advantages of NAD

NAD:  1、“Bonzyme” Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2、Stable supplier of 1000+ enterprises around the world 3、Unique “Bonpure” seven-step purification technology, higher product content and higher conversion rate 4、Freeze drying technology to ensure stable product quality 5、Unique crystal technology, higher product solubility 6、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products

Advantages of MNM

MNM:  1、“Bonzyme”Whole-enzymatic method, environmental-friendly, no harmful solvent residues 2、Exclusive“Bonpure”seven-step purification technology, high purity(up to 99.9%) and stability 3、Industrial leading technology: 15 domestic and international NMN patents 4、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products 5、Multiple in vivo studies show that Bontac NMN is safe and effective 6、Provide one-stop product solution customization service 7、NMN raw material supplier of famous David Sinclair team of Harvard University

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Bontac Bio-Engineering (Shenzhen) Co., Ltd. was established in July 2012, we are a high-tech enterprise integrating R&D, production and sales, with enzyme catalysis technology as core value and coenzyme and natural products as main products.
Bontac is the leader of the global NMN industry. We have the first whole-enzyme catalysis technology in China, and have become the leading enterprise in coenzyme products which are widely used in health industry, medical & beauty, green agriculture, biomedicine fields and other .
Bontac adheres to independent innovation. We have applied for more than 160 invention patents, and have undertaken a number of provincial and national science projects. We are the only approved “coenzyme engineering technology research center” in China.
In the future, Bontac will continue to subvert the traditional chemical synthesis and fermentation industry with our advantages of green low-carbon, low-cost, high-value-added biosynthesis technology, and build ecological relationships with academia, upstream and downstream lean partners, the synthetic biological industry and create a better life for human beings.
Bontac is the first enterprise in the world to achieve mass production of NMN, Bontac is the first coenzyme manufacturer to obtain Kosher certification in China.

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NAD powder efficacy in health

Molecules that can be taken in supplement form to increase NAD levels in the body are referred to by some as “NAD boosters.” Studies conducted over the past six decades suggest that the following are some of the many benefits associated with taking an NAD supplement:
Can Help Restore Mitochondrial Function
Helps Repair Blood Vessels —A 2018 mice study found that supplementation could aid in repair and growth of aged blood vessels. There’s also some evidence it can help manage heart disease risk factors like high blood pressure and high cholesterol.
May Improve Muscle Function — One animal study conducted in 2016 found that degenerative muscles had improved muscle function when supplemented with NAD+ precursors.
Potentially Helps Repair Cells and Damaged DNA — Some studies have found evidence that NAD+ precursor supplementation leads to an increase in DNA damage repair. NAD+ is broken down into two component parts, nicotinamide and ADP-ribose, which combine with proteins to repair cells.
May Help Improve Cognitive Function — Several studies conducted on mice have found that mice treated with NAD+ precursors experienced improvements in cognitive function, learning and memory. Findings have led researchers to believe that NAD supplement may help protect against cognitive decline/Alzheimer’s disease.
May Help Prevent Age-Related Weight Gain — A 2012 study showed that when mice fed a high-fat diet were given an NAD supplement, they gained 60 percent less weight than they did on the same diets without the supplement. One reason this may be true is that nicotinamide adenine dinucleotide helps regulate production of stress- and appetite-related hormones, thanks to its effects on circadian rhythms.
Precursors are molecules used in chemical reactions inside the body to create other compounds. There are a number of precursors of NAD+ that result in higher levels when you consume enough of them.

NAD powder efficacy in health

NAD powder manufacturing method

The preparation methods utilized by manufacturers worldwide of NAD powder are mainly divided into chemical synthesis method and biocatalytic method, among which biocatalytic method includes biological fermentation method and enzyme catalysis method. Enzyme catalysis method has gradually become the mainstream direction because of its advantages of green, environmental protection and pollution-free. And then the purity of NAD powder will reach 99% after the procedure of further purifying. But some NAD manufacturers tend to choose the multiple methods to develop the producing of NAD.

NAD powder manufacturing method

BONTAC NAD product features and advantages

1、As an advanced technology NAD manufacturer,  BONTAC  choose the Enzymatic method, environmental-friendly, no harmful solvent residues manufacturing powder 
2、High purity(up to 99%) and stability of production of NAD powder 
3、Self-owned factories and obtained a number of international certifications to ensure high quality and stable supply of products of NAD powder  
4、Multiple in vivo studies show that Bontac NAD powder is safe and effective
5、Provide one-stop product solution customization service

BONTAC NAD product features and advantages
User Reviews

What users say about BONTAC

BONTAC is a reliable partner that we have been working with for many years. The purity of their coenzyme is very high. Their COA can achieve relatively high test results.


I discovered BONTAC in 2014 because David's article in cell about NAD and NMN related showed that he used BONTAC's NMN for his experimental material. Then we found them in China. After so many years of cooperation, I think it is a very good company.


I think green, healthy and high purity are the advantages of BONTAC's products compared with others. I still work with them to this day.


In 2017, we chose BONTAC's coenzyme, during which our team encountered many technical problems and consulted their technical team, which were able to give us good solutions. Their products are shipped very fast and they work more efficiently.

Frequently Asked Question

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1.Prevention and treatment of viral-induced inflammatory storms
Scientists have found after extensive research that neo-coronavirus has a mechanism similar to SARS virus to activate inflammatory vesicles NLRP3. and the activation of NLRP3 produces more inflammatory factors, generating excessive inflammation and thus triggering a deadly cytokine storm. This problem can be well addressed by NAD+, which inhibits the activity of NF-κB inflammatory pathway and NLRP3 inflammasome by increasing the activity of sirtuins (SIRT1, SIRT2 and SIRT3), thus preventing cytokine storm caused by excessive inflammation. Therefore, Sinclair and other scientists believe that increasing the concentration of NAD+ may play an important role in the prevention and treatment of neocoronavirus and other viral infections.
2.Restoration of virus-induced metabolic disorders
NAD+ is an essential coenzyme for many cellular energy metabolic pathways, present in every cell of the body, involved in thousands of reactions, and an important player in maintaining cellular viability. In the COVID-19 infection model, NAD+ and NMN supplementation was found to be effective in alleviating cell death and protecting the lung.

First, inspect the factory. After some screening, NAD manufactures that directly face consumers pay more attention to brand building. Therefore, for a good brand, quality is the most important thing, and the first thing to control the quality of raw materials is to inspect the factory. Bontac company actually manufacturing NAD powder of high quality with the caterias of SGS. Secondly, the purity is tested. Purity is one of the most important parameters of NAD powder. If high purity NAD cannot be guaranteed, the remaining substances are likely to exceed the relevant standards. As the attached certificates demonstrates that the NAD powder produced by Bontac reach the purity of 99.9%. Finally, a professional test spectrum is needed to prove it. Common methods for determining the structure of an organic compound include Nuclear Magnetic Resonance Spectroscopy (NMR) and high-resolution mass spectrometry (HRMS). Usually through the analysis of these two spectra, the structure of the compound can be preliminarily determined.

In the international market, NAD+ food supplements are in production in the United States, the Australian Food and Drug Administration has approved NAD+ products for sale, and Japanese NAD+ manufactures are devoted to extend the market share in China. Li Ka-shing invested HK$200 million in the US NAD manufacturer, whose NAD+ products are being sold by Watsons in Hong Kong! Then Mclane, a company owned by Warren Buffett also joined the NAD market.

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